Openly accessible

Parent initiated prednisolone for acute asthma in children of school age : randomised controlled crossover trial

Vuillermin, P. J., Robertson, C. F., Carlin, J. B., Brennan, S. L., Biscan, M. I. and South, M. 2010, Parent initiated prednisolone for acute asthma in children of school age : randomised controlled crossover trial, BMJ, vol. 340, no. 7745, pp. 1-8, doi: 10.1136/bmj.c843.

Attached Files
Name Description MIMEType Size Downloads

Title Parent initiated prednisolone for acute asthma in children of school age : randomised controlled crossover trial
Author(s) Vuillermin, P. J.ORCID iD for Vuillermin, P. J. orcid.org/0000-0002-6580-0346
Robertson, C. F.
Carlin, J. B.
Brennan, S. L.ORCID iD for Brennan, S. L. orcid.org/0000-0003-3269-5401
Biscan, M. I.
South, M.
Journal name BMJ
Volume number 340
Issue number 7745
Start page 1
End page 8
Total pages 8
Publisher BMJ Group
Place of publication London, England
Publication date 2010-03-06
ISSN 0959-535X
1468-5833
Keyword(s) placebo
prednisolone
redipred
unclassified drug
Summary Objective To evaluate the efficacy of a short course of parent initiated oral prednisolone for acute asthma in children of school age.

Design Double blind, randomised, placebo controlled, crossover trial in which episodes of asthma, rather than participants, were randomised to treatment.

Setting The Barwon region of Victoria, Australia.

Participants Children aged 5-12 years with a history of recurrent episodes of acute asthma.

Intervention A short course of parent initiated treatment with prednisolone (1 mg/kg a day) or placebo.

Main outcome measures The primary outcome measure was the mean daytime symptom score over seven days. Secondary outcome measures were mean night time symptom score over seven days, use of health resources, and school absenteeism.

Results 230 children were enrolled in the study. Over a three year period, 131 (57%) of the participants contributed a total of 308 episodes of asthma that required parent initiated treatment: 155 episodes were treated with parent initiated prednisolone and 153 with placebo. The mean daytime symptom score was 15% lower in episodes treated with prednisolone than in those treated with placebo (geometric mean ratio 0.85, 95% CI 0.74 to 0.98; P=0.023). Treatment with prednisolone was also associated with a 16% reduction in the night time symptom score (geometric mean ratio 0.84, 95% CI 0.70 to 1.00; P=0.050), a reduced risk of health resource use (odds ratio 0.54, 95% CI 0.34 to 0.86; P=0.010), and reduced school absenteeism (mean difference −0.4 days, 95% CI −0.8 to 0.0 days; P=0.045).

Conclusion A short course of oral prednisolone initiated by parents when their child experiences an episode of acute asthma may reduce asthma symptoms, health resource use, and school absenteeism. However, the modest benefits of this strategy must be balanced against potential side effects of repeated short courses of an oral corticosteroid.
Language eng
DOI 10.1136/bmj.c843
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047629

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in TR Web of Science
Scopus Citation Count Cited 19 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 496 Abstract Views, 5 File Downloads  -  Detailed Statistics
Created: Thu, 30 Aug 2012, 09:50:05 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.