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Reduced planum temporale volume and delusional behaviour in patients with schizophrenia

Yamasaki, Syudo, Yamasue, Hidenori, Abe, Osamu, Yamada, Haruyasu, Iwanami, Akira, Hirayasu, Yoshio, Nakamura, Motoaki, Furukawa, Shun-ichi, Rogers, Mark A., Tanno, Yoshihiko, Aoki, Shigeki, Kato, Nobumasa and Kasai, Kiyoto 2007, Reduced planum temporale volume and delusional behaviour in patients with schizophrenia, European archives of psychiatry and clinical neuroscience, vol. 257, no. 6, pp. 318-324, doi: 10.1007/s00406-007-0723-5.

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Title Reduced planum temporale volume and delusional behaviour in patients with schizophrenia
Author(s) Yamasaki, Syudo
Yamasue, Hidenori
Abe, Osamu
Yamada, Haruyasu
Iwanami, Akira
Hirayasu, Yoshio
Nakamura, Motoaki
Furukawa, Shun-ichi
Rogers, Mark A.ORCID iD for Rogers, Mark A. orcid.org/0000-0002-6808-9545
Tanno, Yoshihiko
Aoki, Shigeki
Kato, Nobumasa
Kasai, Kiyoto
Journal name European archives of psychiatry and clinical neuroscience
Volume number 257
Issue number 6
Start page 318
End page 324
Total pages 7
Publisher Springer Medizin
Place of publication Heidelberg, Germany
Publication date 2007-09
ISSN 0940-1334
1433-8491
Keyword(s) schizophrenia
MRI
planum temporale
superior temporal gyrus
delusion
Summary The structural abnormality of planum temporale (PT), a part of the superior temporal heteromodal association cortex involved in auditory and language processing, has been implicated in the pathophysiology of schizophrenia. However, its relationship to clinical manifestations remains unclear. Magnetic resonance images were obtained from 17 right-handed Japanese men with schizophrenia and from 22 age-, handedness-, and parental socioeconomic-status-matched healthy Japanese men in order to manually evaluate grey matter volumes of Heschl’s gyrus (HG) and PT. Psychiatric symptoms were assessed using positive and negative syndrome scale among the patients. Compared with healthy participants, patients with schizophrenia were associated with a statistically significant PT grey matter volume reduction without left or right lateralization, whereas HG volume was preserved. Smaller right PT volume was significantly correlated with more severe delusional behaviour in the patients. Previous investigations have focused on smaller-than-normal left PT in the pathophysiology of schizophrenia; however, the present results suggest a possible role of the right PT, which is involved in social cognition such as understanding the intentions of others, in the production of psychotic experiences in patients with schizophrenia.
Language eng
DOI 10.1007/s00406-007-0723-5
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047638

Document type: Journal Article
Collection: School of Psychology
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