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Impact of depression treatment on mental and physical health-related quality of life of cardiac patients : a meta-analysis

O'Neil, Adrienne, Sanderson, Kristy, Oldenburg, Brian and Taylor, C. Barr 2011, Impact of depression treatment on mental and physical health-related quality of life of cardiac patients : a meta-analysis, Journal of cardiopulmonary rehabilitation and prevention, vol. 31, no. 3, pp. 146-156, doi: 10.1097/HCR.0b013e3181fc0985.

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Title Impact of depression treatment on mental and physical health-related quality of life of cardiac patients : a meta-analysis
Author(s) O'Neil, Adrienne
Sanderson, Kristy
Oldenburg, Brian
Taylor, C. Barr
Journal name Journal of cardiopulmonary rehabilitation and prevention
Volume number 31
Issue number 3
Start page 146
End page 156
Total pages 11
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, Pa.
Publication date 2011-05
ISSN 1932-7501
1932-751X
Keyword(s) depression treatment
health-related quality of life
mental health functioning
myocardial infarction
physical health functioning
Summary PURPOSE: To conduct a meta-analysis evaluating the effectiveness of depression treatment on mental and physical health-related quality of life (HRQOL) of cardiac patients.

METHODS: Studies were identified using medical, health, psychiatry, psychology, and social sciences databases. Inclusion criteria were (1) 1 or more control conditions, (2) random assignment to condition after admission for myocardial infarction (MI)/acute coronary syndrome, after recording positive results on a depression screener, (3) documentation of depression symptoms at baseline, (4) depression management as a component of the rehabilitation/intervention, (5) validated measure of HRQOL as an outcome, at minimum 6-month followup. For meta-analysis, mental and physical HRQOL were the end points studied, using standardized mean differences for continuous outcome measures, with 95% confidence intervals. Heterogeneity was explored by calculating I2 statistic.

RESULTS: Five randomized controlled trials included in the analysis represented 2105 participants (1058 intervention vs 1047 comparator). Compared with a comparator group at 6 months, a test for overall effect demonstrated statistically significant improvements in mental HRQOL in favor of the intervention (standardized mean differences = −0.29 [−0.38 to −0.20], [P < .00001]; I2 = 0%). Depression treatment had a modest yet significant impact on physical HRQOL (standardized mean differences = −0.14 [−0.24 to −0.04] [P = .009]; I2 = 15%).

CONCLUSION: While the impact of post-MI depression interventions on physical HRQOL is modest, treatment can improve mental HRQOL in a significant way. Future research is required to develop and evaluate a program that can achieve vital improvements in overall HRQOL, and potentially cardiovascular outcomes, of cardiac patients.
Language eng
DOI 10.1097/HCR.0b013e3181fc0985
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047658

Document type: Journal Article
Collection: School of Medicine
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