Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature

Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. 2012, Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature, Journal of neuropsychiatry and clinical neuroscience, vol. 24, no. 1, pp. 102-110.

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Title Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature
Author(s) Chopra, Amit
Tye, Susannah J.
Lee, Kendall H.
Sampson, Shirlene
Matsumoto, Joseph
Adams, Andrea
Klassen, Bryan
Stead, Matt
Fields, Julie A.
Frye, Mark A.
Journal name Journal of neuropsychiatry and clinical neuroscience
Volume number 24
Issue number 1
Start page 102
End page 110
Total pages 9
Publisher American Psychiatric Publishing
Place of publication Arlington, Va.
Publication date 2012-01
ISSN 0895-0172
1545-7222
Keyword(s) high-frequency stimulation
pallidal stimulation
movement-disorders
striatal dopamine
follow-up
psychotic symptoms
secondary mania
basal ganglia
rats
metabolism
Summary Deep brain stimulation (DBS) is a novel and effective surgical intervention for refractory Parkinson's disease (PD). The authors review the current literature to identify the clinical correlates associated with subthalamic nucleus (STN) DBS-induced hypomania/mania in PD patients. Ventromedial electrode placement has been most consistently implicated in the induction of STN DBS-induced mania. There is some evidence of symptom amelioration when electrode placement is switched to a more dorsolateral contact. Additional clinical correlates may include unipolar stimulation, higher voltage (>3 V), male sex, and/or early-onset PD. STN DBS-induced psychiatric adverse events emphasize the need for comprehensive psychiatric presurgical evaluation and follow-up in PD patients. Animal studies and prospective clinical research, combined with advanced neuroimaging techniques, are needed to identify clinical correlates and underlying neurobiological mechanisms of STN DBS-induced mania. Such working models would serve to further our understanding of the neurobiological underpinnings of mania and contribute valuable new insight toward development of future DBS mood-stabilization therapies.
Language eng
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective 920111 Nervous System and Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, American Psychiatric Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047679

Document type: Journal Article
Collection: School of Psychology
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Created: Thu, 30 Aug 2012, 11:24:46 EST by Jane Moschetti

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