Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature

Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature

Chopra, Amit, Tye, Susannah J., Lee, Kendall H., Sampson, Shirlene, Matsumoto, Joseph, Adams, Andrea, Klassen, Bryan, Stead, Matt, Fields, Julie A. and Frye, Mark A. 2012, Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature, Journal of neuropsychiatry and clinical neuroscience, vol. 24, no. 1, pp. 102-110.

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Title	Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature
Author(s)	Chopra, Amit Tye, Susannah J. Lee, Kendall H. Sampson, Shirlene Matsumoto, Joseph Adams, Andrea Klassen, Bryan Stead, Matt Fields, Julie A. Frye, Mark A.
Journal name	Journal of neuropsychiatry and clinical neuroscience
Volume number	24
Issue number	1
Start page	102
End page	110
Total pages	9
Publisher	American Psychiatric Publishing
Place of publication	Arlington, Va.
Publication date	2012-01
ISSN	0895-0172 1545-7222
Keyword(s)	high-frequency stimulation pallidal stimulation movement-disorders striatal dopamine follow-up psychotic symptoms secondary mania basal ganglia rats metabolism
Summary	Deep brain stimulation (DBS) is a novel and effective surgical intervention for refractory Parkinson's disease (PD). The authors review the current literature to identify the clinical correlates associated with subthalamic nucleus (STN) DBS-induced hypomania/mania in PD patients. Ventromedial electrode placement has been most consistently implicated in the induction of STN DBS-induced mania. There is some evidence of symptom amelioration when electrode placement is switched to a more dorsolateral contact. Additional clinical correlates may include unipolar stimulation, higher voltage (>3 V), male sex, and/or early-onset PD. STN DBS-induced psychiatric adverse events emphasize the need for comprehensive psychiatric presurgical evaluation and follow-up in PD patients. Animal studies and prospective clinical research, combined with advanced neuroimaging techniques, are needed to identify clinical correlates and underlying neurobiological mechanisms of STN DBS-induced mania. Such working models would serve to further our understanding of the neurobiological underpinnings of mania and contribute valuable new insight toward development of future DBS mood-stabilization therapies.
Language	eng
Field of Research	170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Socio Economic Objective	920111 Nervous System and Disorders
HERDC Research category	C1 Refereed article in a scholarly journal
Copyright notice	©2012, American Psychiatric Association
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30047679

Document type:	Journal Article
Collection:	School of Psychology

Citation counts:	Cited 0 times in TR Web of Science Cited 1 times in Scopus
Access Statistics:	23 Abstract Views, 1 File Downloads - Detailed Statistics
Created:	Thu, 30 Aug 2012, 11:24:46 EST by Jane Moschetti

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Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's Disease : a review of the literature

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