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Effect of deep brain stimulation on nucleus accumbens dopamine in a preclinicla model of antidepressant treatment-resistance

Tye, Susannah, Anderson, Rodney, Hasebe, Kyoko, Mayberg, Helen, Frye, Mark, Berk, Michael, Choi, Doo-Sup, Blaha, Charles, Garris, Paul and Lee, Kendall 2011, Effect of deep brain stimulation on nucleus accumbens dopamine in a preclinicla model of antidepressant treatment-resistance, in 66th Annual Meeting of the Society of Biological Psychiatry : Paradigm Shifts in the Treatment of Psychiatric Disorders: Past Lessons, Current Trends, Future Possibilities, [Society of Biological Psychiatry], [San Francisco, Calif.].

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Title Effect of deep brain stimulation on nucleus accumbens dopamine in a preclinicla model of antidepressant treatment-resistance
Author(s) Tye, Susannah
Anderson, Rodney
Hasebe, Kyoko
Mayberg, Helen
Frye, Mark
Berk, Michael
Choi, Doo-Sup
Blaha, Charles
Garris, Paul
Lee, Kendall
Conference name Society of Biological Psychiatry Annual Meeting (66th : 2011 : San Francisco, Calif.)
Conference location San Francisco, Calif.
Conference dates 12-14 May 2011
Title of proceedings 66th Annual Meeting of the Society of Biological Psychiatry : Paradigm Shifts in the Treatment of Psychiatric Disorders: Past Lessons, Current Trends, Future Possibilities
Editor(s) [Unknown]
Publication date 2011
Conference series Society of Biological Psychiatry Annual Meeting
Publisher [Society of Biological Psychiatry]
Place of publication [San Francisco, Calif.]
Summary Background / Purpose: To determine if clinically effective deep brain stimulation (DBS) of neurosurgical targets for treatment-resistant depression regulates transient mesoaccumbens dopamine release in control and antidepressant-resistant animals (rats).

Main conclusion: In control rats, DBS stimulation of either the nucleus accumbens or infralimbic cortex significantly attenuated transient mesoaccumbens dopamine efflux, with nucleus accumbens DBS inducing a greater attenuation than infralimbic DBS. High frequency DBS of both targets induced long-term depression of transient accumbens dopamine release, lasting > 2hr post DBS.

Conversely, in antidepressant-resistant rats, infralimbic DBS significantly potentiated transient mesoaccumbens dopamine efflux during stimulation, but failed to induce long-lasting changes in neurotransmission. This suggests that a key mechanism of DBS for treatment-resistant depression is the regulation of dysfunctional mesoaccumbens dopamine neurotransmission.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category E3.1 Extract of paper
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047684

Document type: Conference Paper
Collection: School of Medicine
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Created: Thu, 30 Aug 2012, 12:05:34 EST by Jane Moschetti