Mg-Zr-Sr alloys as biodegradable implant materials

Li, Yuncang, Wen, Cuie, Mushahary, Dolly, Sravanthi, Ragamouni, Harishankar, Nemani, Pande, Gopal and Hodgson, Peter 2012, Mg-Zr-Sr alloys as biodegradable implant materials, Acta biomaterialia, vol. 8, no. 8, pp. 3177-3188, doi: 10.1016/j.actbio.2012.04.028.

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Title Mg-Zr-Sr alloys as biodegradable implant materials
Author(s) Li, Yuncang
Wen, Cuie
Mushahary, Dolly
Sravanthi, Ragamouni
Harishankar, Nemani
Pande, Gopal
Hodgson, Peter
Journal name Acta biomaterialia
Volume number 8
Issue number 8
Start page 3177
End page 3188
Total pages 12
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-08
ISSN 1742-7061
Keyword(s) biocompatibility
bone regeneration
mechanical properties
Mg-Zr-Sr alloys
Summary Novel Mg–Zr–Sr alloys have recently been developed for use as biodegradable implant materials. The Mg–Zr–Sr alloys were prepared by diluting Mg–Zr and Mg–Sr master alloys with pure Mg. The impact of Zr and Sr on the mechanical and biological properties has been thoroughly examined. The microstructures and mechanical properties of the alloys were characterized using optical microscopy, X-ray diffraction and compressive tests. The corrosion resistance was evaluated by electrochemical analysis and hydrogen evolution measurement. The in vitro biocompatibility was assessed using osteoblast-like SaOS2 cells and MTS and haemolysis tests. In vivo bone formation and biodegradability were studied in a rabbit model. The results indicated that both Zr and Sr are excellent candidates for Mg alloying elements in manufacturing biodegradable Mg alloy implants. Zr addition refined the grain size, improved the ductility, smoothed the grain boundaries and enhanced the corrosion resistance of Mg alloys. Sr addition led to an increase in compressive strength, better in vitro biocompatibility, and significantly higher bone formation in vivo. This study demonstrated that Mg–xZr–ySr alloys with x and y ⩽5 wt.% would make excellent biodegradable implant materials for load-bearing applications.
Language eng
DOI 10.1016/j.actbio.2012.04.028
Field of Research 029999 Physical Sciences not elsewhere classified
Socio Economic Objective 870302 Metals (e.g. Composites, Coatings, Bonding)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Acta Materialia
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Document type: Journal Article
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