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Microbial lipases : at the interface of aqueous and non-aqueous media: a review

Verma, M. L., Azmi, W. and Kanwar, S. S. 2008, Microbial lipases : at the interface of aqueous and non-aqueous media: a review, Acta microbiologica et immunologica Hungarica, vol. 55, no. 3, pp. 265-294.

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Title Microbial lipases : at the interface of aqueous and non-aqueous media: a review
Author(s) Verma, M. L.
Azmi, W.
Kanwar, S. S.
Journal name Acta microbiologica et immunologica Hungarica
Volume number 55
Issue number 3
Start page 265
End page 294
Total pages 30
Publisher Akadémiai Kiadó
Place of publication Budapest, Hungary
Publication date 2008-09
ISSN 1217-8950
1588-2640
Keyword(s) Ester synthesis and advances in lipase catalysis
lipase modifications
lipase stability
microbial lipase
non-aqueous media
Summary In recent times, biotechnological applications of microbial lipases in synthesis of many organic molecules have rapidly increased in non-aqueous media. Microbial lipases are the working horses' in biocatalysis and have been extensively studied when their exceptionally high stability in non-aqueous media has been discovered. Stability of lipases in organic solvents makes them commercially feasibile in the enzymatic esterification reactions. Their stability is affected by temperature, reaction medium, water concentration and by the biocatalyst's preparation. An optimization process for ester synthesis from pilot scale to industrial scale in the reaction medium is discussed. The water released during the esterification process can be controlled over a wide range and has a profound effect on the activity of the lipases. Approaches to lipase catalysis like protein engineering, directed evolution and metagenome approach were studied. This review reports the recent development in the field of non-aqueous microbial lipase catalysis and factors controlling the esterification/transesterification processes in organic media.
Language eng
Field of Research 100301 Biocatalysis and Enzyme Technology
100306 Industrial Molecular Engineering of Nucleic Acids and Proteins
100703 Nanobiotechnology
Socio Economic Objective 860106 Oils and Fats (incl. Margarines)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, Akadémiai Kiadó
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047725

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.