Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization

Zhou, Min, Li, Puwang, Wang, Guang, Yang, Ziming, Peng, Zheng and Kong, Lingxue 2012, Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization, Applied mechanics and materials, vol. 466-467, pp. 454-457.

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Title Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization
Author(s) Zhou, Min
Li, Puwang
Wang, Guang
Yang, Ziming
Peng, Zheng
Kong, Lingxue
Journal name Applied mechanics and materials
Volume number 466-467
Start page 454
End page 457
Total pages 4
Publisher Trans Tech Publications
Place of publication Stafa-Zurich, Switzerland
Publication date 2012
ISSN 1660-9336
1662-7482
Keyword(s) folic acid
chitosan
vanillin
chemical modification
Summary Functionalized chitosan (CS) were widely used as drug delivery system in the chemotherapy of various disease. In this work, folate (FA) was conjugated into chitosan molecular as targeting ligand based on Schiff reaction between –NH2 group of CS and –COOH group of FA. And nanoparticles were made by emulsion method with vanillin novel cross-linking agent. The FA modified CS and its nanoparticles were characterized by Fourier transform spectroscopy (FT-IR), scanning electron microscope (SEM) and Zeta potential. SEM results confirmed the nanoparticles made from FA-CS conjugate were spherical in shape and were about 100 nm in size. Zeta potential analysis revealed that the nanoparticles were negatively charged with charge density of -7.73mV.
Language eng
Field of Research 099999 Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Trans Tech Publications, Switzerland
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047741

Document type: Journal Article
Collection: Institute for Frontier Materials
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