Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands Kalia, S. B., Kaushal, G., Kumar, M., Cameotra, S. S., Sharma, A., Verma, M. L. and Kanwar, S. S. 2009, Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands, Brazilian journal of microbiology, vol. 40, no. 4, pp. 916-922, doi: 10.1590/S1517-83822009000400024. Attached Files Name Description MIMEType Size Downloads Title Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands Author(s) Kalia, S. B. Kaushal, G. Kumar, M. Cameotra, S. S. Sharma, A. Verma, M. L. Kanwar, S. S. Journal name Brazilian journal of microbiology Volume number 40 Issue number 4 Start page 916 End page 922 Total pages 7 Publisher Sociedade Brasileira de Microbiologia Place of publication Rio de Janeiro, Brazil Publication date 2009-10 ISSN 1517-8382 1678-4405 Keyword(s) antimicrobial metal ions 4-methylpiperazine-1-carbodithioate MIC zone of inhibition Summary A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4-MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate; phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa,Staphylococcus aureus and Enterococcusfaecalis by disk diffusion method. All the complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC values in the range <8-512 μgmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4-MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 µgmL-1.The complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells (RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes. Language eng DOI 10.1590/S1517-83822009000400024 Field of Research 100301 Biocatalysis and Enzyme Technology 100306 Industrial Molecular Engineering of Nucleic Acids and Proteins 100703 Nanobiotechnology Socio Economic Objective 860106 Oils and Fats (incl. Margarines) HERDC Research category C1.1 Refereed article in a scholarly journal Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30047764 Document type: Journal Article Collection: School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 03 Sep 2012, 13:56:21 EST Mon, 01 Oct 2012, 10:20:52 EST Mon, 01 Oct 2012, 10:23:14 EST Thu, 11 Dec 2014, 18:07:41 EST Fri, 26 Aug 2016, 14:58:23 EST Mon, 05 Sep 2016, 15:43:37 EST Filtered Full Citation counts:   Cited 11 times in TR Web of Science Cited 11 times in Scopus Search Google Scholar Access Statistics: 73 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Mon, 03 Sep 2012, 13:56:21 EST

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