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Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands

Kalia, S. B., Kaushal, G., Kumar, M., Cameotra, S. S., Sharma, A., Verma, M. L. and Kanwar, S. S. 2009, Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands, Brazilian journal of microbiology, vol. 40, no. 4, pp. 916-922.

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Title Antimicrobial and toxicological studies of some metal complexes of 4-methylpiperazine-1-carbodithioate and phenanthroline mixed ligands
Author(s) Kalia, S. B.
Kaushal, G.
Kumar, M.
Cameotra, S. S.
Sharma, A.
Verma, M. L.
Kanwar, S. S.
Journal name Brazilian journal of microbiology
Volume number 40
Issue number 4
Start page 916
End page 922
Total pages 7
Publisher Sociedade Brasileira de Microbiologia
Place of publication Rio de Janeiro, Brazil
Publication date 2009-10
ISSN 1517-8382
1678-4405
Keyword(s) antimicrobial
metal ions
4-methylpiperazine-1-carbodithioate
MIC
zone of inhibition
Summary A few mixed ligand transition metal carbodithioate complexes of the general formula [M(4-MPipzcdt)x(phen)y]Y (M = Mn(II), Co(II), Zn(II); 4-MPipzcdt = 4-methylpiperazine-1-carbodithioate; phen = 1,10-phenanthroline; x = 1 and y = 2 when Y = Cl; x = 2 and y = 1 when Y = nil) were synthesized and screened for their antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa,Staphylococcus aureus and Enterococcusfaecalis by disk diffusion method. All the complexes exhibited prominent antimicrobial activity against tested pathogenic strains with the MIC values in the range <8-512 μgmL-1. The complexes [Mn(4-MPipzcdt)2(phen)] and [Co(4-MPipzcdt)(phen)2]Cl inhibited the growth of Candida albicans at a concentration as low as 8 µgmL-1.The complexes were also evaluated for their toxicity towards human transformed rhabdomyosarcoma cells (RD cells). Moderate cell viability of the RD cells was exhibited against the metal complexes.
Language eng
Field of Research 100301 Biocatalysis and Enzyme Technology
100306 Industrial Molecular Engineering of Nucleic Acids and Proteins
100703 Nanobiotechnology
Socio Economic Objective 860106 Oils and Fats (incl. Margarines)
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047764

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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