A discussion on the process of defining 2-D separation selectivity

Stevenson, Paul G., Mnatsakanyan, Mariam, Francis, Andrew R. and Shalliker, R. Andrew 2010, A discussion on the process of defining 2-D separation selectivity, Journal of separation science, vol. 33, no. 10, pp. 1405-1413.

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Title A discussion on the process of defining 2-D separation selectivity
Author(s) Stevenson, Paul G.
Mnatsakanyan, Mariam
Francis, Andrew R.
Shalliker, R. Andrew
Journal name Journal of separation science
Volume number 33
Issue number 10
Start page 1405
End page 1413
Total pages 9
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Place of publication Weinheim, Germany
Publication date 2010-06
ISSN 1615-9306
1615-9314
Keyword(s) 2-D-HPLC
orthogonality
selectivity
solute selection
Summary In this manuscript, we investigate the importance that must be placed on the selection of standard compounds when undertaking studies to optimize the performance of 2-D-HPLC separations. A geometric approach to factor analysis and a measure of peak density across the separation space were applied to assess localized measures of component distributions within the 2-D separation plane. The results of this analysis of data showed that the measure of separation quality varied markedly, depending on the elution zone for which the test was undertaken. The study concluded that if standards cannot be obtained that adequately describe the entire sample matrix, the sample itself should be used, and also, the separation should be optimized for regions of interest, not necessarily the separation as a whole.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047844

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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