Chicken anemia virus : an understanding of the in-vitro host response over time

Crowley, Tamsyn M., Haring, Volker R. and Moore, Robert 2011, Chicken anemia virus : an understanding of the in-vitro host response over time, Viral immunology, vol. 24, no. 1, pp. 3-9.

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Title Chicken anemia virus : an understanding of the in-vitro host response over time
Author(s) Crowley, Tamsyn M.
Haring, Volker R.
Moore, Robert
Journal name Viral immunology
Volume number 24
Issue number 1
Start page 3
End page 9
Total pages 7
Publisher Mary Ann Liebert Publishers
Place of publication New Rochelle, N. Y.
Publication date 2011-02-01
ISSN 0882-8245
1557-8976
Keyword(s) animals
cell Line
chicken anemia virus
chickens
cytokines
gene Expression Profiling
host-Pathogen Interactions
microarray Analysis
time Factors
Summary Chicken anemia virus (CAV) is an economically important virus affecting the chicken meat and egg industry. CAV is characterized by anemia, lymphoid depletion, and immunosuppression. Microarrays were used to investigate the response of MDCC-MSB1 cells (MSB1) to infection with CAV at 24 and 48 h post-infection (hpi). The major genes responding to CAV infection include genes involved in inflammation, apoptosis, and antiviral activity. Several cytokines were differentially regulated at either 24 or 48 hpi, including interleukin 2 (IL-2), interleukin receptors IL-1R, IL-22R, IL-18R, and IL-7R, and interferon-α (IFN-α). While there were many genes differentially regulated in this experiment, only two genes were common to both time points, suggesting a dramatic change in gene expression over the two time points studied. The present study is the first microarray experiment to investigate CAV, and we identified a number of key pathways involved in viral infection. Overall, there were more genes upregulated at 24 hpi than at 48 hpi, including genes involved in cytokine signaling, apoptosis, and antiviral activity. The two time points were vastly different in their gene expression patterns, in that at 24 hpi there were many genes involved in the response to infection, whereas at 48 hpi there were many genes associated with apoptosis and immunosuppression.
Language eng
Field of Research 060408 Genomics
060506 Virology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Mary Ann Liebert, Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047938

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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