Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and oocyte maturation in female coho salmon (Oncorhynchus kisutch) during vitellogenesis

Afonso, L. O. B., Iwama, G. K., Smith, J. and Donaldson, E. M. 1999, Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and oocyte maturation in female coho salmon (Oncorhynchus kisutch) during vitellogenesis, Fish physiology and biochemistry, vol. 20, no. 3, pp. 231-241.

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Title Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and oocyte maturation in female coho salmon (Oncorhynchus kisutch) during vitellogenesis
Formatted title Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and oocyte maturation in female coho salmon (Oncorhynchus kisutch) during vitellogenesis
Author(s) Afonso, L. O. B.
Iwama, G. K.
Smith, J.
Donaldson, E. M.
Journal name Fish physiology and biochemistry
Volume number 20
Issue number 3
Start page 231
End page 241
Total pages 11
Publisher Kluwer Academic Publishers
Place of publication Amsterdam, The Netherlands
Publication date 1999-03
ISSN 0920-1742
1573-5168
Keyword(s) 17α-20β-dihydroxy-4-pregnen-3-one
17β-estradiol
Aromatase
Atresia
Brain
Oocytes
Salmon
Testosterone
Summary 17β-estradiol, 17α-20β-dihydroxy-4-pregnen-3-one (17α-20β-P), and testosterone levels were measured in plasma samples obtained from vitellogenic coho salmon (Oncorhynchus kisutch) before and 32 days after injection of the aromatase inhibitor Fadrozole (AI). Plasma 17β-estradiol levels decreased significantly 6 h after injection in all AI treated fish. The higher the dose the longer the maintenance of low plasma 17β-estradiol levels. Inversely, plasma 17α-20β-P increased significantly 6 h after injection in all AI treated fish, and the higher the dose the longer the maintenance of high plasma 17α-20β-P levels. At 48 h after injection plasma testosterone levels were significantly higher in the AI treated groups. The oocyte maturation index showed that multiple injections with AI retarded oocyte development. Besides, oocyte diameter and GSI were lower in the same group, which presented high incidence of atresia of vitellogenic oocytes. The ovarian follicles and brain of the fish which received multiple injections secreted less 17β-estradiol, in vitro. These findings suggest that aromatase inhibitors such as Fadrozole may have a potential as a tool to regulate sexual development in salmon.
Language eng
Field of Research 060408 Genomics
070401 Aquaculture
Socio Economic Objective 830102 Aquaculture Fin Fish (excl. Tuna)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©1999, Kluwer Academic Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047946

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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