Application of power functions to chromatographic data for the enhancement of signal to noise ratios and separation resolution

Shalliker, R. A., Stevenson, P. G., Shock, D., Mnatsakanyan, M., Dasgupta, P. K. and Guiochon, G. 2010, Application of power functions to chromatographic data for the enhancement of signal to noise ratios and separation resolution, Journal of chromatography A, vol. 1217, no. 36, pp. 5693-5699.

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Title Application of power functions to chromatographic data for the enhancement of signal to noise ratios and separation resolution
Author(s) Shalliker, R. A.
Stevenson, P. G.
Shock, D.
Mnatsakanyan, M.
Dasgupta, P. K.
Guiochon, G.
Journal name Journal of chromatography A
Volume number 1217
Issue number 36
Start page 5693
End page 5699
Total pages 7
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2010-09-03
ISSN 0021-9673
1873-3778
Keyword(s) data smoothing
DPPH
gaussian
HPLC
signal to noise
two-dimensional HPLC
Summary Chromatographic detection responses are recorded digitally. A peak is represented ideally by a Guassian distribution. Raising a Guassian distribution to the power ‘n’ increases the height of the peak to that power, but decreases the standard deviation by √n. Hence there is an increasing disparity in detection responses as the signal moves from low level noise, with a corresponding decrease in peak width. This increases the S/N ratio and increases peak to peak resolution. The ramifications of these factors are that poor resolution in complex chromatographic data can be improved, and low signal responses embedded at near noise levels can be enhanced. The application of this data treatment process is potentially very useful in 2D-HPLC where sample dilution occurs between dimension, reducing signal response, and in the application of post-reaction detection methods, where band broadening is increased by virtue of reaction coils. In this work power functions applied to chromatographic data are discussed in the context of (a) complex separation problems, (b) 2D-HPLC separations, and (c) post-column reaction detectors.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047993

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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