Performance of columns packed with the new shell particles, Kinetex-C18

Gritti, Fabrice, Leonardis, Irene, Shock, David, Stevenson, Paul, Shalliker, Andrew and Guiochon, Georges 2010, Performance of columns packed with the new shell particles, Kinetex-C18, Journal of chromatography A, vol. 1217, no. 10, pp. 1589-1603.

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Title Performance of columns packed with the new shell particles, Kinetex-C18
Formatted title Performance of columns packed with the new shell particles, Kinetex-C18
Author(s) Gritti, Fabrice
Leonardis, Irene
Shock, David
Stevenson, Paul
Shalliker, Andrew
Guiochon, Georges
Journal name Journal of chromatography A
Volume number 1217
Issue number 10
Start page 1589
End page 1603
Total pages 15
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2010-03-05
ISSN 0021-9673
1873-3778
Keyword(s) acetonitrile
anthracene
bradykinin
column packing technology
Halo-C 18
HETP
insulin
Kinetex-C 18
lyzozyme
naphtho[2,3-a]pyrene
shell particles
Van Deemter plot
Summary The performance of the new Kinetex-C18 column was investigated. Packed with a new brand of porous shell particles, this column has an outstanding efficiency. Once corrected for the contribution of the instrument extra column volume, the minimum values of the reduced plate heights for a number of low molecular weight compounds (e.g., anthracene and naphtho[2,3-a]pyrene) were between 1.0 and 1.3, breaking the legendary record set 3 years ago by Halo-C18 packed columns. The liquid-solid mass transfer of proteins (e.g., insulin and lyzozyme) is exceptionally fast on Kinetex-C18 much faster than on the Halo-C18 column. The different contributions of dispersion and mass transfer resistances to the column efficiency were determined and discussed. The possible reasons for this extremely high column efficiency are discussed.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier B.V.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30047997

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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