Regulation of glycogen synthase and phosphorylase during recovery from high-intensity exercise in the rat

Brau, Lambert, Ferreira, Luis D. M. C. B., Nikolovski, Sasha, Raja, Ghazala, Palmer, T. Norman and Fournier, Paul A. 1997, Regulation of glycogen synthase and phosphorylase during recovery from high-intensity exercise in the rat, Biochemical journal, vol. 322, no. 1, pp. 303-308.

Attached Files
Name Description MIMEType Size Downloads

Title Regulation of glycogen synthase and phosphorylase during recovery from high-intensity exercise in the rat
Author(s) Brau, Lambert
Ferreira, Luis D. M. C. B.
Nikolovski, Sasha
Raja, Ghazala
Palmer, T. Norman
Fournier, Paul A.
Journal name Biochemical journal
Volume number 322
Issue number 1
Start page 303
End page 308
Total pages 6
Publisher Portland Press
Place of publication London, England
Publication date 1997-02-15
ISSN 0264-6021
1470-8728
Keyword(s) animals
enzyme activation
glycogen
glycogen synthase
male
skeletal muscle
phosphorylases
phosphorylation
animal physical conditioning
rats
Wistar rats
Summary The aim of this study was to determine the role of the phosphorylation state of glycogen synthase and glycogen phosphorylase in the regulation of muscle glycogen repletion in fasted animals recovering from high-intensity exercise. Groups of rats were swum to exhaustion and allowed to recover for up to 120 min without access to food. Swimming to exhaustion caused substantial glycogen breakdown and lactate accumulation in the red, white and mixed gastrocnemius muscles, whereas the glycogen content in the soleus muscle remained stable. During the first 40 min of recovery, significant repletion of glycogen occurred in all muscles examined except the soleus muscle. At the onset of recovery, the activity ratios and fractional velocities of glycogen synthase in the red, white and mixed gastrocnemius muscles were higher than basal, but returned to pre-exercise levels within 20 min after exercise. In contrast, after exercise the activity ratios of glycogen phosphorylase in the same muscles were lower than basal, and increased to pre-exercise levels within 20 min. This pattern of changes in glycogen synthase and phosphorylase activities, never reported before, suggests that the integrated regulation of the phosphorylation state of both glycogen synthase and phosphorylase might be involved in the control of glycogen deposition after high-intensity exercise.
Language eng
Field of Research 110102 Medical Biochemistry: Carbohydrates
110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30048051

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 32 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 22 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 03 Sep 2012, 15:22:17 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.