Repeated bouts of high-intensity exercise and muscle glycogen sparing in the rat

Raja, Ghazala, Brau, Lambert, Palmer, T. Norman and Fournier, Paul A. 2003, Repeated bouts of high-intensity exercise and muscle glycogen sparing in the rat, Journal of experimental biology, vol. 206, pp. 2159-2166.

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Title Repeated bouts of high-intensity exercise and muscle glycogen sparing in the rat
Author(s) Raja, Ghazala
Brau, LambertORCID iD for Brau, Lambert
Palmer, T. Norman
Fournier, Paul A.
Journal name Journal of experimental biology
Volume number 206
Start page 2159
End page 2166
Total pages 8
Publisher Company of Biologists
Place of publication Cambridge, England
Publication date 2003-07-01
ISSN 0022-0949
Keyword(s) exercise
skeletal muscle
Summary Even in the absence of food intake, several animal species recovering from physical activity of high intensity can replenish completely their muscle glycogen stores. In some species of mammals, such as in rats and humans, glycogen repletion is only partial, thus suggesting that a few consecutive bouts of high-intensity exercise might eventually lead to the sustained depletion of their muscle glycogen. In order to test this prediction, groups of rats with a lead weight of 10% body mass attached to their tails were subjected to either one, two or three bouts of high-intensity swimming, each bout being separated from the next by a 1 h recovery period. Although glycogen repletion after the first bout of exercise was only partial, all the glycogen mobilised in subsequent bouts was completely replenished during the corresponding recovery periods and irrespective of muscle fibre compositions. The impact of repeated bouts of high-intensity exercise on plasma levels of fatty acids, acetoacetate and β-hydroxybutyrate suggests that the metabolic state of the rat prior to the second and third bouts of exercise was different from that before the first bout. In conclusion, rats resemble other vertebrate species in that without food intake there are conditions under which they can replenish completely their muscle glycogen stores from endogenous carbon sources when recovering from high-intensity exercise. It remains to be established, however, whether this capacity is typical of mammals in general.
Language eng
Field of Research 110102 Medical Biochemistry: Carbohydrates
110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Company of Biologists
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