Self-assembled peptides : characterisation and in vivo response

Nisbet, David R. and Williams, Richard J. 2012, Self-assembled peptides : characterisation and in vivo response, Biointerphases, vol. 7, no. 2, pp. 1-14.

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Title Self-assembled peptides : characterisation and in vivo response
Author(s) Nisbet, David R.
Williams, Richard J.ORCID iD for Williams, Richard J.
Journal name Biointerphases
Volume number 7
Issue number 2
Start page 1
End page 14
Total pages 14
Publisher Springer
Place of publication New York, N. Y.
Publication date 2012
ISSN 1559-4106
Summary The fabrication of tissue engineering scaffolds is a well-established field that has gained recent prominence for the in vivo repair of a variety of tissue types. Recently, increasing levels of sophistication have been engineered into adjuvant scaffolds facilitating the concomitant presentation of a variety of stimuli (both physical and biochemical) to create a range of favourable cellular microenvironments. It is here that self-assembling peptide scaffolds have shown considerable promise as functional biomaterials, as they are not only formed from peptides that are physiologically relevant, but through molecular recognition can offer synergy between the presentation of biochemical and physio-chemical cues. This is achieved through the utilisation of a unique, highly ordered, nano- to microscale 3-D morphology to deliver mechanical and topographical properties to improve, augment or replace physiological function. Here, we will review the structures and forces underpinning the formation of self-assembling scaffolds, and their application in vivo for a variety of tissue types.
Language eng
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Springer
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