Design and analysis of a multilayer localized surface plasmon resonance graphene biosensor

Islam, Md.Saiful, Kouzani, Abbas Z., Dai, Xiujuan J., Michalski, Wojtek P. and Gholamhosseini, Hamid 2012, Design and analysis of a multilayer localized surface plasmon resonance graphene biosensor, Journal of biomedical nanotechnology, vol. 8, no. 3, pp. 380-393.

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Title Design and analysis of a multilayer localized surface plasmon resonance graphene biosensor
Author(s) Islam, Md.Saiful
Kouzani, Abbas Z.ORCID iD for Kouzani, Abbas Z.
Dai, Xiujuan J.
Michalski, Wojtek P.
Gholamhosseini, Hamid
Journal name Journal of biomedical nanotechnology
Volume number 8
Issue number 3
Start page 380
End page 393
Total pages 14
Publisher American Scientific Publishers
Place of publication Valencia, Calif.
Publication date 2012-06
ISSN 1550-7033
Keyword(s) biosensor
evanescent wave
Kretschmann configuration
localized surface plasmon resonance
signal to noise ratio
Summary This paper describes a multilayer localized surface plasmon resonance (LSPR) graphene biosensor that includes a layer of graphene sheet on top of the gold layer, and the use of different coupled configuration of a laser beam. The study also investigates the enhancement of the sensitivity and detection accuracy of the biosensor through monitoring biomolecular interactions of biotin-streptavidin with the graphene layer on the gold thin film. Additionally, the role of thin films of gold, silver, copper and aluminum in the performance of the biosensor is separately investigated for monitoring the binding of streptavidin to the biotin groups. The performance of the LSPR graphene biosensor is theoretically and numerically assessed in terms of sensitivity, adsorption efficiency, and detection accuracy under varying conditions, including the thickness of biomolecule layer, number of graphene layers and operating wavelength. Enhanced sensitivity and improved adsorption efficiency are obtained for the LSPR graphene biosensor in comparison with its conventional counterpart; however, detection accuracy under the same resonance condition is reduced by 5.2% with a single graphene sheet. This reduction in detection accuracy (signal to noise ratio) can be compensated for by introducing an additional layer of silica doped B2O3 (sdB2O3) placed under the graphene layer. The role of prism configuration, prism angle and the interface medium (air and water) is also analyzed and it is found that the LSPR graphene biosensor has better sensitivity with triangular prism, higher prism angle, lower operating wavelength and larger number of graphene layers. The approach involves a plot of a reflectivity curve as a function of the incidence angle. The outcomes of this investigation highlight the ideal functioning condition corresponding to the best design parameters.
Language eng
Field of Research 090606 Photonics and Electro-Optical Engineering (excl Communications)
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, American Scientific Publishers
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