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Clostridial spores for cancer therapy : targeting solid tumour microenvironment

Umer, Brittany, Good, David, Anne, Jozef, Duan, Wei and Wei, Ming Q. 2012, Clostridial spores for cancer therapy : targeting solid tumour microenvironment, Journal of toxicology, vol. 2012, Article ID 862764, pp. 1-8.

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Title Clostridial spores for cancer therapy : targeting solid tumour microenvironment
Author(s) Umer, Brittany
Good, David
Anne, Jozef
Duan, Wei
Wei, Ming Q.
Journal name Journal of toxicology
Volume number 2012
Season Article ID 862764
Start page 1
End page 8
Total pages 8
Publisher Hindawi Publishing Corporation
Place of publication New York, N.Y.
Publication date 2012
ISSN 1687-8205
Keyword(s) solid tumour
clostridial Spores
cancer therapy
Summary Solid tumour accounts for 90% of all cancers. The current treatment approach for most solid tumours is surgery, however it is limited to early stage tumours. Other treatment options such as chemotherapy and radiotherapy are non-selective, thus causing damage to both healthy and cancerous tissue. Past research has focused on understanding tumour cells themselves, and conventional wisdom has aimed at targeting these cells directly. Recent research has shifted towards understanding the tumour microenvironment and it’s differences from that of healthy cells/tissues in the body and then to exploit these differences for treatmeat of the tumour. One such approach is utilizing anaerobic bacteria. Several strains of bacteria have been shown to selectively colonize in solid tumours, making them valuable tools for selective tumour targeting and destruction. Amongst them, the anaerobic Clostridium has shown great potential in penetration and colonization of the hypoxic and necrotic areas of the tumour microenvironment, causing significant oncolysis as well as enabling the delivery of therapeutics directly to the tumour in situ. Various strategies utilizing Clostridium are currently being investigated, and represent a novel area of emerging cancer therapy. This review provides an update review of tumour microenvironment as well as summary of the progresses and current status of Clostridial spore-based cancer therapies.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Brittany Umer et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30049024

Document type: Journal Article
Collections: School of Medicine
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Created: Tue, 23 Oct 2012, 14:08:20 EST by Linda Aldridge