Ribosome-inactivating proteins : current status and biomedical applications

Puri, Munish, Kaur, Inderdeep, Perugini, Matthew A. and Gupta, Raghbir C. 2012, Ribosome-inactivating proteins : current status and biomedical applications, Drug discovery today, vol. 17, no. 13-14, pp. 774-783.

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Title Ribosome-inactivating proteins : current status and biomedical applications
Author(s) Puri, MunishORCID iD for Puri, Munish orcid.org/0000-0003-2469-3326
Kaur, Inderdeep
Perugini, Matthew A.
Gupta, Raghbir C.
Journal name Drug discovery today
Volume number 17
Issue number 13-14
Start page 774
End page 783
Total pages 10
Publisher Elsevier
Place of publication London, England
Publication date 2012-07
ISSN 1359-6446
Summary Ribosome-inactivating proteins (RIPs) are mainly present in plants and function to inhibit protein synthesis through the removal of adenine residues from eukaryotic ribosomal RNA (rRNA). They are broadly classified into two groups: type I and type II. Type I RIPs are a diverse family of proteins comprising a single polypeptide chain, whereas type II RIPs are heterodimeric glycoproteins comprising an A-chain (functionally equivalent to a type I RIP) linked via a disulphide bond to a B chain, mediating cell entry. In this review, we describe common type I and type II RIPs, their diverse biological functions, mechanism of cell entry, stability in plasma and antigenicity. We end with a discussion of promising applications for RIPs in biomedicine.
Language eng
Field of Research 100302 Bioprocessing, Bioproduction and Bioproducts
030406 Proteins and Peptides
060506 Virology
Socio Economic Objective 860303 Plant Extracts (e.g. Pyrethrum, Alkaloids, Jojoba Oil)
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30049597

Document type: Journal Article
Collection: Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin)
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