Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach

Ghanizadeh, Ahmad, Berk, Michael, Farrashbandi, Hassan, Alavi shoushtari, Ali and Villagonzalo, Kristi-Ann 2013, Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach, Mitochondrion, vol. 13, no. 5, pp. 515-519.

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Title Targeting the mitochondrial electron transport chain in autism, a systematic review and synthesis of a novel therapeutic approach
Author(s) Ghanizadeh, Ahmad
Berk, Michael
Farrashbandi, Hassan
Alavi shoushtari, Ali
Villagonzalo, Kristi-Ann
Journal name Mitochondrion
Volume number 13
Issue number 5
Start page 515
End page 519
Total pages 5
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2013-09
ISSN 1567-7249
Keyword(s) mitochondria
etiology
oxidative stress
energy
treatment
autism
Summary Autism is a complex developmental disorder with an unknown etiology and without any curative treatment. The mitochondrial electron transfer chains play a major role in the production of ATP, and the generation and management of reactive oxidative stress (ROS). This paper is a systematic review of the role of the mitochondrial electron transport chain in autism, and a consequent hypothesis for treating autism is synthesized.

An electronic search with pre-specified inclusion criteria was conducted in order to retrieve all the published articles about the mitochondrial electron transport chain in autism. The two databases of PUBMED and Google Scholar were searched.

From one hundred twenty five retrieved titles, 12 (three case control study and 9 case reports) articles met inclusion criteria. All of the included studies indicated dysfunction of electron transport chain in autism.

The mitochondrial electron transfer chain seems impaired in some children with autism and ROS production is additionally enhanced. It is hypothesized that interventions involving alternative electron shuttling may improve autism through lowering the production of ROS. In addition, it is expected that this alternative electron shuttling to cytochrome c might enhance the production of ATP which is impaired in the disorder.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050068

Document type: Journal Article
Collection: School of Medicine
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