The regulation and function of the striated muscle activator of rho signaling (STARS) protein

Wallace, Marita A., Lamon, Severine and Russell, Aaron P. 2012, The regulation and function of the striated muscle activator of rho signaling (STARS) protein, Frontiers in physiology, vol. 3, no. Article 469, pp. 1-5.

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Title The regulation and function of the striated muscle activator of rho signaling (STARS) protein
Author(s) Wallace, Marita A.
Lamon, Severine
Russell, Aaron P.
Journal name Frontiers in physiology
Volume number 3
Issue number Article 469
Start page 1
End page 5
Total pages 5
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2012-12
ISSN 1664-042X
Keyword(s) ABRA
smooth muscle
skeletal muscle
cardiac muscle
Summary Healthy living throughout the lifespan requires continual growth and repair of cardiac, smooth, and skeletal muscle. To effectively maintain these processes muscle cells detect extracellular stress signals and efficiently transmit them to activate appropriate intracellular transcriptional programs. The striated muscle activator of Rho signaling (STARS) protein, also known as Myocyte Stress-1 (MS1) protein and Actin-binding Rho-activating protein (ABRA) is highly enriched in cardiac, skeletal, and smooth muscle. STARS binds actin, co-localizes to the sarcomere and is able to stabilize the actin cytoskeleton. By regulating actin polymerization, STARS also controls an intracellular signaling cascade that stimulates the serum response factor (SRF) transcriptional pathway; a pathway controlling genes involved in muscle cell proliferation, differentiation, and growth. Understanding the activation, transcriptional control and biological roles of STARS in cardiac, smooth, and skeletal muscle, will improve our understanding of physiological and pathophysiological muscle development and function.
Language eng
Field of Research 111603 Systems Physiology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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