Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes

Hussey, S. E., McGee, S. L., Garnham, A., Wentworth, J. M., Jeukendrup, A. E. and Hargreaves, M. 2011, Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes, Diabetes, obesity and metabolism, vol. 13, no. 10, pp. 959-962.

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Title Exercise training increases adipose tissue GLUT4 expression in patients with type 2 diabetes
Author(s) Hussey, S. E.
McGee, S. L.
Garnham, A.
Wentworth, J. M.
Jeukendrup, A. E.
Hargreaves, M.
Journal name Diabetes, obesity and metabolism
Volume number 13
Issue number 10
Start page 959
End page 962
Total pages 4
Publisher Wiley-Blackwell Publishing Ltd.
Place of publication West Sussex, England
Publication date 2011-10
ISSN 1462-8902
Keyword(s) adipocyte
skeletal muscle
insulin resistance
glucose uptake
Summary We investigated the effects of exercise training on adipose tissue and skeletal muscle GLUT4 expression in patients with type 2 diabetes (T2D). Muscle and adipose tissue samples were obtained before and after 4-weeks of exercise training in seven patients with T2D [47 ± 2 years, body mass index (BMI) 28 ± 2]. Seven control subjects (54 ± 4, BMI 30 ± 2) were recruited for baseline comparison. Adipose tissue GLUT4 protein expression was 43% lower (p < 0.05) in patients with T2D compared with control subjects and exercise training increased (p < 0.05) adipose tissue GLUT4 expression by 36%. Skeletal muscle GLUT4 protein expression was not different between control subjects and patients with T2D. Exercise training increased (p < 0.05) skeletal muscle GLUT4 protein expression by 20%. In conclusion, 4-weeks of exercise training increased GLUT4 expression in adipose tissue and skeletal muscle of patients with T2D, although the functional benefits of this adaptation appear to be dependent on an optimal β-cell function.
Language eng
Field of Research 110602 Exercise Physiology
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050100

Document type: Journal Article
Collection: School of Medicine
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