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Using lithium as a neuroprotective agent in patients with cancer

Khasraw, Mustafa, Ashley, David, Wheeler, Greg and Berk, Michael 2012, Using lithium as a neuroprotective agent in patients with cancer, BMC Medicine, vol. 10, no. 131, pp. 1-7.

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Title Using lithium as a neuroprotective agent in patients with cancer
Author(s) Khasraw, Mustafa
Ashley, David
Wheeler, Greg
Berk, Michael
Journal name BMC Medicine
Volume number 10
Issue number 131
Start page 1
End page 7
Total pages 7
Publisher BioMed Central
Place of publication London, England
Publication date 2012-11-02
ISSN 1741-7015
Keyword(s) acute lymphoblastic leukemia
Alzheimer disease
bipolar disorder
brain disease
brain metastasis
brain radiation
brain tumor
cancer chemotherapy
cancer patient
cancer radiotherapy
Summary Neurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a consequence of either chemotherapy-related or radiotherapy-related complications. Brain radiotherapy in particular can lead to significant cognitive defects. Neurocognitive decline adversely affects quality of life, meaningful employment, and even simple daily activities. Neuroprotection may be a viable and realistic goal in preventing neurocognitive sequelae in these patients, especially in the setting of cranial irradiation. Lithium is an agent that has been in use for psychiatric disorders for decades, but recently there has been emerging evidence that it can have a neuroprotective effect.

This review discusses neurocognitive impairment in patients with cancer and the potential for investigating the use of lithium as a neuroprotectant in such patients.
Notes This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Language eng
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Khasraw et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050134

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.