Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

Hussey, S. E., McGee, S. L., Garnham, A., McConell, G. K. and Hargreaves, M. 2012, Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes, Diabetes, obesity and metabolism, vol. 14, no. 8, pp. 768-771.

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Title Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes
Author(s) Hussey, S. E.
McGee, S. L.
Garnham, A.
McConell, G. K.
Hargreaves, M.
Journal name Diabetes, obesity and metabolism
Volume number 14
Issue number 8
Start page 768
End page 771
Total pages 4
Publisher Wiley - Blackwell
Place of publication Oxford, England
Publication date 2012-08
ISSN 1462-8902
1463-1326
Keyword(s) exercise
glucose metabolism
type 2 diabetes
Summary The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ∼55% peak power (Wmax). Skeletal muscle biopsies were obtained at baseline, immediately post and 3-h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (∼60%) and T2D (∼66%) subjects, and remained elevated (p < 0.05) 3-h post exercise with no differences between groups. Similarly, p-AMP-activated protein kinase, p38 mitogen-activated kinase and proliferator-activated receptor gamma co-activator-alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.
Language eng
Field of Research 110602 Exercise Physiology
Socio Economic Objective 920104 Diabetes
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050136

Document type: Journal Article
Collection: School of Medicine
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