Role of multidrug resistance associated proteins in drug development

Zhou, Shu-Feng, Liu, Jun-Ping, Wei, Ming Qian and Duan, Wei 2012, Role of multidrug resistance associated proteins in drug development. In Khan, Asad U. and Zarrilli, Raffaele (ed), Multidrug resistance : a global concern, Bentham Science Publishers, [San Francisco, Calif.], pp.3-35.

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Title Role of multidrug resistance associated proteins in drug development
Author(s) Zhou, Shu-Feng
Liu, Jun-Ping
Wei, Ming Qian
Duan, WeiORCID iD for Duan, Wei
Title of book Multidrug resistance : a global concern
Editor(s) Khan, Asad U.
Zarrilli, Raffaele
Publication date 2012
Chapter number 1
Total chapters 13
Start page 3
End page 35
Total pages 33
Publisher Bentham Science Publishers
Place of Publication [San Francisco, Calif.]
Keyword(s) ATP-binding cassette superfamily
multidrug resistance
blood-brain barrier
drug toxicity
genetic mutations
tumor resistance
transpofting proteins
drug-drug interactions
Summary The Multidrug Resistance Associated Proteins (MRPI, MRP2, MRP3, MRp4, MRp5, MRP6, MRP7, MRPS and MRP9) belong to the ATP-binding cassette superfamily (ABCC family) of transporters expressed differentially in the liver, kidney, intestine and blood-brain barrier. MRps transport a structurally diverse array of endo- and xenobiotics and their metabolites (in particular conjugates) and are subject to induction and inhibition by a variety of compounds. An increased efflux of natural product anticancer drugs and other anticancer agents by MRPs in cancer cells is associated with tumor resistance. These transporting proteins play a role in the absorption, distribution and elimination of various compounds in the body. There are increased reports on the clinical impact of genetic mutations of genes encoding MRP1-9. Therefore, MRPs have an important role in drug development, since a better understanding of their function and regulating mechanism can help minimize and avoid drug toxicity, unfavorable drug-drug interactions, and to overcome drug resistance.
ISBN 9781608052929
Language eng
Field of Research 111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
Socio Economic Objective 920101 Blood Disorders
HERDC Research category B1 Book chapter
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Document type: Book Chapter
Collection: School of Medicine
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