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Co-prescription of medication for bipolar disorder and diabetes mellitus : a nationwide population based study with focus on gender differences

Svendal, Gjertrud, Fasmer, Ole Bernt, Engeland, Anders, Berk, Michael and Lund, Anders 2012, Co-prescription of medication for bipolar disorder and diabetes mellitus : a nationwide population based study with focus on gender differences, BMC medicine, vol. 10, Article number148, pp. 1-6.

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Title Co-prescription of medication for bipolar disorder and diabetes mellitus : a nationwide population based study with focus on gender differences
Author(s) Svendal, Gjertrud
Fasmer, Ole Bernt
Engeland, Anders
Berk, Michael
Lund, Anders
Journal name BMC medicine
Volume number 10
Season Article number148
Start page 1
End page 6
Total pages 6
Publisher BioMed Central
Place of publication England, London
Publication date 2012
ISSN 1741-7015
Keyword(s) bipolar disorder
diabetes mellitus
gender
Summary Background
Studies have shown a correlation between bipolar disorder and diabetes mellitus. It is unclear if this correlation is a part of common pathophysiological pathways, or if medication for bipolar disorder has negative effects on blood sugar regulation.
Methods
The Norwegian prescription database was analyzed. Prescriptions for lithium, lamotrigine, carbamazepine and valproate were used as proxies for bipolar disorder. Prescriptions for insulin and oral anti-diabetic agents were used as proxies for diabetes mellitus. We explored the association between medication for bipolar disorder and diabetes medication by logistic regression
Results
We found a strong association between concomitant use of medication to treat diabetes mellitus and mood stabilizers for the treatment of bipolar disorder. Females had a 30% higher risk compared to men of being treated for both disorders. Persons using oral anti-diabetic agents had higher odds of receiving valproate than either lithium or lamotrigine. Use of insulin as monotherapy seemed to have lower odds than oral anti-diabetic agents of co-prescription of mood stabilizers, compared to the general population.
Conclusions
This study showed a strong association between the use of mood stabilizers and anti-diabetic agents. The association was stronger among women than men.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050626

Document type: Journal Article
Collections: School of Medicine
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Created: Mon, 18 Feb 2013, 10:44:48 EST by Jane Moschetti