Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension

Begg, Denovan P., Puskas, Laszlo G., Kitajka, Klara, Menesi, Dalma, Allen, Andrew M., Li, Duo, Mathai, Michael L., Shi, Jian R., Sinclair, Andrew J. and Weisinger, Richard S. 2012, Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension, Hypertension research, vol. 35, no. 4, pp. 381-387, doi: 10.1038/hr.2011.194.

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Title Hypothalamic gene expression in w-3 PUFA-deficient male rats before, and following, development of hypertension
Author(s) Begg, Denovan P.
Puskas, Laszlo G.
Kitajka, Klara
Menesi, Dalma
Allen, Andrew M.
Li, Duo
Mathai, Michael L.
Shi, Jian R.
Sinclair, Andrew J.
Weisinger, Richard S.
Journal name Hypertension research
Volume number 35
Issue number 4
Start page 381
End page 387
Total pages 7
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2012-04
ISSN 0916-9636
Keyword(s) adrenergic
gene expression
ω-3 fatty acids
Summary Dietary deficiency of ω-3 fatty acids (ω-3 DEF) produces hypertension in later life. This study examined the effect of ω-3 DEF on blood pressure and hypothalamic gene expression in young rats, before the development of hypertension, and in older rats following the onset of hypertension. Animals were fed experimental diets that were deficient in ω-3 fatty acids, sufficient in short-chain ω-3 fatty acids or sufficient in short- and long-chain ω-3 fatty acids, from the prenatal period until 10 or 36 weeks-of-age. There was no difference in blood pressure between groups at 10 weeks-of-age; however, at 36 weeks-of-age ω-3 DEF animals were hypertensive in relation to sufficient groups. At 10 weeks, expression of angiotensin-II1A receptors and dopamine D3 receptors were significantly increased in the hypothalamic tissue of ω-3 DEF animals. In contrast, at 36 weeks, α2a and β1 adrenergic receptor expression was significantly reduced in the ω-3 DEF group. Brain docosahexaenoic acid was significantly lower in ω-3 DEF group compared with sufficient groups. This study demonstrates that dietary ω-3 DEF causes changes both in the expression of key genes involved in central blood pressure regulation and in blood pressure. The data may indicate that hypertension resulting from ω-3 DEF is mediated by the central adrenergic system.
Language eng
DOI 10.1038/hr.2011.194
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050697

Document type: Journal Article
Collection: School of Medicine
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