Effects of N-acetyl cysteine on cognitive function in bipolar disorder

Dean, Olivia M., Bush, Ashley I., Copolov, David L., Kohlmann, Kristy, Jeavons, Susan, Schapkaitz, Ian, Anderson-Hunt, Murray and Berk, Michael 2012, Effects of N-acetyl cysteine on cognitive function in bipolar disorder, Psychiatry and clinical neurosciences, vol. 66, no. 6, pp. 514-517, doi: 10.1111/j.1440-1819.2012.02392.x.

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Title Effects of N-acetyl cysteine on cognitive function in bipolar disorder
Author(s) Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Bush, Ashley I.
Copolov, David L.
Kohlmann, Kristy
Jeavons, Susan
Schapkaitz, Ian
Anderson-Hunt, Murray
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Psychiatry and clinical neurosciences
Volume number 66
Issue number 6
Start page 514
End page 517
Total pages 4
Publisher Wiley-Blackwell Publishing Asia
Place of publication Richmond, Vic.
Publication date 2012-10
ISSN 1323-1316
Keyword(s) bipolar disorder
N-acetyl cysteine
clinical trial
Summary Aims

Bipolar disorder is characterized by progressive changes in cognition with declines in executive functioning, memory and sustained attention. Current pharmacotherapies for bipolar disorder target mood symptoms but have not addressed these cognitive changes resulting in euthymic individuals who still experience cognitive deficits. N-acetyl cysteine (NAC) has been shown to have effects on antioxidant status, glutamate transmission, inflammation and neurogenesis. Adjunctive treatment with NAC improves the symptoms experienced by those with bipolar disorder, particularly depression, and it was hypothesized that cognition may also be improved following NAC treatment.

As part of a larger randomized, double-blind, placebo-controlled trial, participants in the current report were tested at baseline and 6 months to assess changes in cognitive function following either 2000 mg of NAC daily or placebo.

This study failed to find changes in cognitive function following treatment with NAC compared to placebo.

While an important pilot study, this study had a small sample size and included a limited battery of cognitive tests. Further investigations on the effects of NAC on cognitive performance in bipolar disorder are required.
Language eng
DOI 10.1111/j.1440-1819.2012.02392.x
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Wiley-Blackwell Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050703

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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