Effects of N-acetyl cysteine on cognitive function in bipolar disorder Dean, Olivia M., Bush, Ashley I., Copolov, David L., Kohlmann, Kristy, Jeavons, Susan, Schapkaitz, Ian, Anderson-Hunt, Murray and Berk, Michael 2012, Effects of N-acetyl cysteine on cognitive function in bipolar disorder, Psychiatry and clinical neurosciences, vol. 66, no. 6, pp. 514-517, doi: 10.1111/j.1440-1819.2012.02392.x. Attached Files Name Description MIMEType Size Downloads Title Effects of N-acetyl cysteine on cognitive function in bipolar disorder Author(s) Dean, Olivia M. orcid.org/0000-0002-2776-3935 Bush, Ashley I. Copolov, David L. Kohlmann, Kristy Jeavons, Susan Schapkaitz, Ian Anderson-Hunt, Murray Berk, Michael orcid.org/0000-0002-5554-6946 Journal name Psychiatry and clinical neurosciences Volume number 66 Issue number 6 Start page 514 End page 517 Total pages 4 Publisher Wiley-Blackwell Publishing Asia Place of publication Richmond, Vic. Publication date 2012-10 ISSN 1323-1316 1440-1819 Keyword(s) bipolar disorder oxidative N-acetyl cysteine cognition clinical trial Summary Aims Bipolar disorder is characterized by progressive changes in cognition with declines in executive functioning, memory and sustained attention. Current pharmacotherapies for bipolar disorder target mood symptoms but have not addressed these cognitive changes resulting in euthymic individuals who still experience cognitive deficits. N-acetyl cysteine (NAC) has been shown to have effects on antioxidant status, glutamate transmission, inflammation and neurogenesis. Adjunctive treatment with NAC improves the symptoms experienced by those with bipolar disorder, particularly depression, and it was hypothesized that cognition may also be improved following NAC treatment. Methods As part of a larger randomized, double-blind, placebo-controlled trial, participants in the current report were tested at baseline and 6 months to assess changes in cognitive function following either 2000 mg of NAC daily or placebo. Results This study failed to find changes in cognitive function following treatment with NAC compared to placebo. Conclusions While an important pilot study, this study had a small sample size and included a limited battery of cognitive tests. Further investigations on the effects of NAC on cognitive performance in bipolar disorder are required. Language eng DOI 10.1111/j.1440-1819.2012.02392.x Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2012, Wiley-Blackwell Publishing Persistent URL http://hdl.handle.net/10536/DRO/DU:30050703 Document type: Journal Article Collection: School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 19 Feb 2013, 13:55:14 EST Wed, 27 Feb 2013, 17:11:05 EST Thu, 07 Mar 2013, 09:06:35 EST Thu, 07 Mar 2013, 09:07:24 EST Fri, 19 Jul 2013, 10:02:25 EST Fri, 13 Jun 2014, 16:37:53 EST Filtered Full Citation counts:   Cited 20 times in TR Web of Science Cited 20 times in Scopus Search Google Scholar Access Statistics: 559 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Tue, 19 Feb 2013, 13:54:58 EST by Jane Moschetti

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