Developmental origins of obesity-related hypertension

Henry, Sarah L., Barzel, Benjamin, Wood-Bradley, Ryan J., Burke, Sandra L., Head, Geoffrey A. and Armitage, James A. 2012, Developmental origins of obesity-related hypertension, Clinical and experimental pharmacology and physiology, vol. 39, no. 9, pp. 799-806, doi: 10.1111/j.1440-1681.2011.05579.x.

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Title Developmental origins of obesity-related hypertension
Author(s) Henry, Sarah L.
Barzel, Benjamin
Wood-Bradley, Ryan J.
Burke, Sandra L.
Head, Geoffrey A.
Armitage, James A.ORCID iD for Armitage, James A.
Journal name Clinical and experimental pharmacology and physiology
Volume number 39
Issue number 9
Start page 799
End page 806
Total pages 8
Publisher Blackwell Asia Publishing
Place of publication Richmond, Vic.
Publication date 2012-09
ISSN 0305-1870
Keyword(s) developmental programming of health and disease
sympathetic nervous system
placental transfer
obesity-related hypertension
maternal diet in pregnancy
fatty acids
Summary 1. In the past 30 years the prevalence of obesity and overweight have doubled. It is now estimated that globally over 500 million adults are obese and a further billion adults are overweight. Obesity is a cardiovascular risk factor and some studies suggest that up to 70% of cases of essential hypertension may be attributable, in part, to obesity. Increasingly, evidence supports a view that obesity-related hypertension may be driven by altered hypothalamic signalling, which results in inappropriately high appetite and sympathetic nerve activity to the kidney.

2. In addition to the adult risk factors for obesity and hypertension, the environment encountered in early life may ‘programme’ the development of obesity, hypertension and cardiovascular disease. In particular, maternal obesity or high dietary fat intake in pregnancy may induce changes in fetal growth trajectories and predispose individuals to develop obesity and related sequelae.

3. The mechanisms underlying the programming of obesity-related hypertension are becoming better understood. However, several issues require clarification, particularly with regard to the role of the placenta in transferring fatty acid to the fetal compartment, the impact of placental inflammation and cytokine production in obesity.

4. By understanding which factors are most associated with the development of obesity and hypertension in the offspring, we can focus therapeutic and behavioural interventions to most efficiently reduce the intergenerational propagation of the obesity cycle.
Language eng
DOI 10.1111/j.1440-1681.2011.05579.x
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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