X-ray velocimetry within the ex vivo carotid artery

Jamison, R. A., Siu, K. K. W., Dubsky, S., Armitage, J. A. and Fouras, Andreas 2012, X-ray velocimetry within the ex vivo carotid artery, Journal of synchrotron radiation, vol. 19, no. 6, pp. 1050-1055, doi: 10.1107/S0909049512033912.

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Title X-ray velocimetry within the ex vivo carotid artery
Author(s) Jamison, R. A.
Siu, K. K. W.
Dubsky, S.
Armitage, J. A.ORCID iD for Armitage, J. A. orcid.org/0000-0002-3762-0911
Fouras, Andreas
Journal name Journal of synchrotron radiation
Volume number 19
Issue number 6
Start page 1050
End page 1055
Total pages 6
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass.
Publication date 2012-11
ISSN 0909-0495
Keyword(s) phase contrast
x-ray velocimetry
blood flow
ex vivo imaging
particle image velocimetry
Summary X-ray velocimetry offers a non-invasive method by which blood flow, blood velocity and wall shear stress can be measured in arteries prone to atherosclerosis. Analytical tools for measuring haemodynamics in artificial arteries have previously been developed and here the first quantification of haemodynamics using X-ray velocimetry in a living mammalian artery under physiologically relevant conditions is demonstrated. Whole blood seeded with a clinically used ultrasound contrast agent was pumped with a steady flow through live carotid arterial tissue from a rat, which was kept alive in a physiological salt solution. Pharmacological agents were then used to produce vascular relaxation. Velocity measurements were acquired with a spatial resolution of 14 µm × 14 µm and at a rate of 5000 acquisitions per second. Subtle velocity changes that occur are readily measurable, demonstrating the ability of X-ray velocimetry to sensitively and accurately measure haemodynamics ex vivo. Future applications and possible limitations of the technique are discussed, which allows for detailed living tissue investigations to be carried out for various disease models, including atherosclerosis and diabetic vasculopathy.
Language eng
DOI 10.1107/S0909049512033912
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050740

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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