You are not logged in.

X-ray velocimetry within the ex vivo carotid artery

Jamison, R. A., Siu, K. K. W., Dubsky, S., Armitage, J. A. and Fouras, Andreas 2012, X-ray velocimetry within the ex vivo carotid artery, Journal of synchrotron radiation, vol. 19, no. 6, pp. 1050-1055, doi: 10.1107/S0909049512033912.

Attached Files
Name Description MIMEType Size Downloads

Title X-ray velocimetry within the ex vivo carotid artery
Author(s) Jamison, R. A.
Siu, K. K. W.
Dubsky, S.
Armitage, J. A.
Fouras, Andreas
Journal name Journal of synchrotron radiation
Volume number 19
Issue number 6
Start page 1050
End page 1055
Total pages 6
Publisher Wiley - Blackwell Publishing
Place of publication Malden, Mass.
Publication date 2012-11
ISSN 0909-0495
1600-5775
Keyword(s) phase contrast
x-ray velocimetry
blood flow
ex vivo imaging
particle image velocimetry
Summary X-ray velocimetry offers a non-invasive method by which blood flow, blood velocity and wall shear stress can be measured in arteries prone to atherosclerosis. Analytical tools for measuring haemodynamics in artificial arteries have previously been developed and here the first quantification of haemodynamics using X-ray velocimetry in a living mammalian artery under physiologically relevant conditions is demonstrated. Whole blood seeded with a clinically used ultrasound contrast agent was pumped with a steady flow through live carotid arterial tissue from a rat, which was kept alive in a physiological salt solution. Pharmacological agents were then used to produce vascular relaxation. Velocity measurements were acquired with a spatial resolution of 14 µm × 14 µm and at a rate of 5000 acquisitions per second. Subtle velocity changes that occur are readily measurable, demonstrating the ability of X-ray velocimetry to sensitively and accurately measure haemodynamics ex vivo. Future applications and possible limitations of the technique are discussed, which allows for detailed living tissue investigations to be carried out for various disease models, including atherosclerosis and diabetic vasculopathy.
Language eng
DOI 10.1107/S0909049512033912
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050740

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in TR Web of Science
Scopus Citation Count Cited 9 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 185 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 21 Feb 2013, 10:37:15 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.