A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue

Handapangoda, Chinta Chamalie, Premaratne, Malin and Nahavandi, Saeid 2012, A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue, in EMBC 2012 : Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, IEEE, Piscataway, N.J., pp. 1494-1497, doi: 10.1109/EMBC.2012.6346224.

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Title A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue
Author(s) Handapangoda, Chinta Chamalie
Premaratne, Malin
Nahavandi, SaeidORCID iD for Nahavandi, Saeid orcid.org/0000-0002-0360-5270
Conference name IEEE Engineering in Medicine and Biology Society. Conference (34th : 2012 : San Diego, California)
Conference location San Diego, California
Conference dates 28 Aug.-1 Sep. 2012
Title of proceedings EMBC 2012 : Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Editor(s) [Unknown]
Publication date 2012
Conference series IEEE Engineering in Medicine and Biology Society Conference
Start page 1494
End page 1497
Total pages 4
Publisher IEEE
Place of publication Piscataway, N.J.
Keyword(s) absorption
biological system modeling
biological tissues
Summary Fluorescence has become a widely used technique for applications in noninvasive diagnostic tissue spectroscopy. The standard model used for characterizing fluorescence photon transport in biological tissue is based on the diffusion approximation. On the premise that the total energy of excitation and fluorescent photon flows must be conserved, we derive the widely used diffusion equations in fluorescence spectroscopy and show that there must be an additional term to account for the transport of fluorescent photons. The significance of this additional term in modeling fluorescence spectroscopy in biological tissue is assessed.
ISBN 1424441196
9781424441198
Language eng
DOI 10.1109/EMBC.2012.6346224
Field of Research 090399 Biomedical Engineering not elsewhere classified
020503 Nonlinear Optics and Spectroscopy
029903 Medical Physics
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category E1 Full written paper - refereed
Persistent URL http://hdl.handle.net/10536/DRO/DU:30050977

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