The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination

Acquaviva, Laurent, Szekvolgyi, Lorant, Dichtl, Berhard, Dichtl, Beatriz Solange, De, la Roche Saint Andre Christophe, Nicolas, Alain and Geli, Vincent 2013, The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination, Science, vol. 339, no. 6116, pp. 215-218.

Attached Files
Name Description MIMEType Size Downloads

Title The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination
Author(s) Acquaviva, Laurent
Szekvolgyi, Lorant
Dichtl, Berhard
Dichtl, Beatriz Solange
De, la Roche Saint Andre Christophe
Nicolas, Alain
Geli, Vincent
Journal name Science
Volume number 339
Issue number 6116
Start page 215
End page 218
Total pages 4
Publisher American Association for the Advancement of Science
Place of publication Washington, D.C.
Publication date 2013
ISSN 0036-8075
1095-9203
Summary During meiosis, combinatorial associations of genetic traits arise from homologous recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks meiotic recombination hotspots in yeast and mammals, but how this ubiquitous chromatin modification relates to the initiation of double-strand breaks (DSBs) dependent on Spo11 remains unknown. Here, we show that the tethering of a PHD-containing protein, Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce DSB formation. Furthermore, we found that Spp1 physically interacts with Mer2, a key protein of the differentiated chromosomal axis required for DSB formation. Thus, by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis, allowing Spo11 cleavage at nearby nucleosome-depleted regions.
Language eng
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, American Association for the Advancement of Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30051600

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in TR Web of Science
Scopus Citation Count Cited 18 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 32 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Thu, 21 Mar 2013, 09:36:43 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.