Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids

Debeljuh, Natalie, Varghese, Swapna, Barrow, Colin J. and Byrne, Nolene 2012, Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids, Australian journal of chemistry, vol. 65, no. 11, pp. 1502-1506.

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Title Role of cation in enhancing the conversion of the Alzheimer's peptide into amyloid fibrils using protic ionic liquids
Author(s) Debeljuh, Natalie
Varghese, Swapna
Barrow, Colin J.
Byrne, Nolene
Journal name Australian journal of chemistry
Volume number 65
Issue number 11
Start page 1502
End page 1506
Total pages 5
Publisher CSIRO Publishing
Place of publication Melbourne, Vic.
Publication date 2012
ISSN 0004-9425
1445-0038
Summary We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the A 16-22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.
Language eng
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, CSIRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30051605

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