This chapter is designed to assist those working with young people to translate the research and understandings on addressing gender, sexuality and bullying presented in this book into practice in schools. Drawing on current research on effective sexuality education, teacher practice, building respectful relationships and addressing gendered based violence, the chapter discusses and presents the key elements of planning and delivering successfully interventions for young people in schools. The chapter focuses on a number of potentially challenging, complex and interrelated gender and sexuality issues common to schools as they attempt to provide safe and supportive learning environments for all young people. Drawing on the Australian experience a range of case studies is presented. Strategies for dealing with issues such as homophobia, gender and violence, sexual harassment, ‘bitch fights’ and pornography are presented and used as examples to assist teachers and other professionals to know when and how to intervene to build more positive and respectful relationships amongst students.