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Approaches, challenges, and experience in assessing free nicotine

Ashley, David L., Pankow, James F., Tavakoli, Ameer D. and Watson, Clifford H. 2009, Approaches, challenges, and experience in assessing free nicotine, Handbook of experimental pharmacology, vol. 192, pp. 437-456, doi: 10.1007/978-3-540-69248-5_15.

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Title Approaches, challenges, and experience in assessing free nicotine
Author(s) Ashley, David L.
Pankow, James F.
Tavakoli, Ameer D.
Watson, Clifford H.
Journal name Handbook of experimental pharmacology
Volume number 192
Start page 437
End page 456
Total pages 20
Publisher Springer New York LLC
Place of publication New York, N.Y.
Publication date 2009
ISSN 0171-2004
Summary Delivery of nicotine in the most desirable form is critical in maintaining people's use of tobacco products. Interpretation of results by tobacco industry scientists, studies that measure free-base nicotine directly in tobacco smoke, and the variability of free-base nicotine in smokeless tobacco products all indicate that the form of nicotine delivered to the tobacco user, in addition to the total amount, is an important factor in whether people continue to use the product following their initial exposure. The physiological impact of nicotine varies with the fraction that is in the free-base form and this leads to continued exposure to other toxic tobacco contents and emissions. In addition to evaluating the total nicotine delivered to the user, measuring the fraction of nicotine in the free-base form is critical in understanding and controlling the influence of nicotine on tobacco use.
Language eng
DOI 10.1007/978-3-540-69248-5_15
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052151

Document type: Journal Article
Collection: School of Medicine
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