Radiotherapy management of patients diagnosed with glioma in Victoria (1998–2000) : a retrospective cohort study

Dally, M., Rosenthal, M., Drummond, K., Murphy, M., Cher, L., Ashley, D., Thursfield, V. and Giles, G. 2009, Radiotherapy management of patients diagnosed with glioma in Victoria (1998–2000) : a retrospective cohort study, Journal of medical imaging and radiation oncology, vol. 53, no. 3, pp. 318-324, doi: 10.1111/j.1754-9485.2009.02072.x.

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Title Radiotherapy management of patients diagnosed with glioma in Victoria (1998–2000) : a retrospective cohort study
Author(s) Dally, M.
Rosenthal, M.
Drummond, K.
Murphy, M.
Cher, L.
Ashley, D.
Thursfield, V.
Giles, G.
Journal name Journal of medical imaging and radiation oncology
Volume number 53
Issue number 3
Start page 318
End page 324
Total pages 7
Publisher Wiley-Blackwell Publishing Asia
Place of publication Melbourne, Vic.
Publication date 2009
ISSN 1754-9477
Keyword(s) cancer registry
pattern of care
Summary This study aimed to describe the radiotherapy (RT) management and subsequent outcome in a cohort of patients with newly diagnosed glioma. Treatment details were obtained via a questionnaire completed by neurosurgeons, radiation and medical oncologists who treated patients diagnosed with glioma in Victoria during 1998–2000. Patients were identified by using the population-based Victorian Cancer Registry. Over the study period, data on 828 patients were obtained, of whom 612 (74%) were referred for consideration of RT. Radiotherapy was given to 496 patients as part of their initial treatment and to an additional 10 patients at the time of tumour recurrence or progression. The median age was 72 (16–85) years. Median overall survival (OS) was 9.2 (standard error (SE) 0.6) months for the entire group. Median OS was 29.1 (SE 8.0) and 7.4 (SE 0.4) months for all patients with histological confirmation of World Health Organization Grades III (anaplastic astrocytoma) and IV (glioblastoma multiforme) histology, respectively. A total of 47 different RT dose fractionation schedules were identified. This is the largest survey detailing management of glioma with RT, published to date. A marked variation in dose fractionation schemes was evident. While current best practice involves the use of chemotherapy in conjunction with RT for glioblastoma multiforme, advances in patient care may be undermined by this variation in the use of RT. Clinical trials relevant to an ageing population and evidence-based national clinical guidelines are required to define best practice.
Language eng
DOI 10.1111/j.1754-9485.2009.02072.x
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Wiley-Blackwell Publishing Asia
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Document type: Journal Article
Collection: School of Medicine
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