An investigation of porphyrinuria in Australian children with autism Austin, David W. and Shandley, Kerrie 2008, An investigation of porphyrinuria in Australian children with autism, Journal of toxicology and environmental health. Part A, vol. 71, no. 20, pp. 1349-1351, doi: 10.1080/15287390802271723. Attached Files Name Description MIMEType Size Downloads Title An investigation of porphyrinuria in Australian children with autism Author(s) Austin, David W. orcid.org/0000-0002-1296-3555 Shandley, Kerrie Journal name Journal of toxicology and environmental health. Part A Volume number 71 Issue number 20 Start page 1349 End page 1351 Total pages 3 Publisher Taylor & Francis Place of publication London, England Publication date 2008 ISSN 1528-7394 1087-2620 Summary Two recent studies, from France (Nataf et al., 200614. Nataf, R., Skorupka, C., Amet, L., Lam, A., Springbett, A. and Lathe, R. 2006. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity. Toxicol. Appl. Pharmacol., 214: 99–108. [CrossRef], [PubMed], [Web of Science ®] View all references) and the United States (Geier & Geier, 20079. Geier, D. A. and Geier, M. R. 2007. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J. Toxicol. Environ. Health, A, 70: 1723–1730. [Taylor & Francis Online], [PubMed], [Web of Science ®] View all references), identified atypical urinary porphyrin profiles in children with an autism spectrum disorder (ASD). These profiles serve as an indirect measure of environmental toxicity generally, and mercury (Hg) toxicity specifically, with the latter being a variable proposed as a causal mechanism of ASD (Bernard et al., 20012. Bernard, S., Enayati, A., Redwood, L., Roger, H. and Binstock, T. 2001. Autism: A novel form of mercury poisoning. Med. Hypoth., 56: 462–471. [CrossRef], [PubMed], [Web of Science ®] View all references; Mutter et al., 200515. Mutter, J., Naumann, J., Schneider, R., Walach, H. and Haley, B. 2005. Mercury and autism: Accelerating evidence?. Neuroendocrinol. Lett., 26: 439–446. [PubMed], [Web of Science ®] View all references). To examine whether this phenomenon occurred in a sample of Australian children with ASD, an analysis of urinary porphyrin profiles was conducted. A consistent trend in abnormal porphyrin levels was evidenced when data was compared with those previously reported in the literature. The results are suggestive of environmental toxic exposure impairing heme synthesis. Three independent studies from three continents have now demonstrated that porphyrinuria is concomitant with ASD, and that Hg may be a likely xenobiotic to produce porphyrin profiles of this nature. Language eng DOI 10.1080/15287390802271723 Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2008, Taylor & Francis Persistent URL http://hdl.handle.net/10536/DRO/DU:30052206 Document type: Journal Article Collection: School of Psychology Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 01 May 2013, 14:07:44 EST Wed, 01 May 2013, 15:25:09 EST Fri, 10 May 2013, 14:31:09 EST Wed, 05 Feb 2014, 11:43:11 EST Fri, 09 May 2014, 14:13:46 EST Thu, 11 Dec 2014, 18:38:42 EST Tue, 06 Jan 2015, 11:45:45 EST Wed, 17 Aug 2016, 08:57:40 EST Tue, 06 Sep 2016, 20:59:49 EST Filtered Full Citation counts:   Cited 33 times in TR Web of Science Cited 34 times in Scopus Search Google Scholar Access Statistics: 330 Abstract Views, 47 File Downloads  -  Detailed Statistics Created: Wed, 01 May 2013, 14:07:44 EST

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