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Gastrointestinal microbiology in autistic spectrum disorder : a review

Gondalia, Shakuntla V., Palombo, Enzo A., Knowles, Simon R. and Austin, David W. 2010, Gastrointestinal microbiology in autistic spectrum disorder : a review, Reviews in medical microbiology, vol. 21, no. 3, pp. 44-50, doi: 10.1097/MRM.0b013e32833a3dc9.

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Title Gastrointestinal microbiology in autistic spectrum disorder : a review
Author(s) Gondalia, Shakuntla V.
Palombo, Enzo A.
Knowles, Simon R.
Austin, David W.ORCID iD for Austin, David W. orcid.org/0000-0002-1296-3555
Journal name Reviews in medical microbiology
Volume number 21
Issue number 3
Start page 44
End page 50
Total pages 7
Publisher Lippincott Williams & Wilkins
Place of publication London, England
Publication date 2010
ISSN 0954-139X
Summary Cases of autism have frequently been reported in association with gastrointestinal problems. These observations have stimulated investigations into possible abnormalities of intestinal microbiota in autistic patients. The objectives of this paper were to review the possible involvement and mechanisms of gastrointestinal microbiota in autistic spectrum disorder and explain the possible role of gastrointestinal microbiota in the condition. This review addresses the possible involvement of bacteria, viruses and fungi, and their products in autism. Direct viral damage of neurons or disruption of normal neurodevelopment by immune elements such as cytokines, nitric oxide and bacterial products, including lipopolysaccharides, toxins and metabolites, have been suggested to contribute to autistic pathology. Numerous intestinal microbial abnormalities have been reported in individuals with autism. Research to date exploring possible gastrointestinal problems and infection in autism has been limited by small and heterogeneous samples, study design flaws and conflicting results. Furthermore, interventions designed to modify the intestinal microbial population of autistic patients are few and limited in their generalisation. In order to bring clarity to this field, high-quality and targeted investigations are needed to explore the role of gastrointestinal microbiology in autism. To this end, several promising avenues for future research are suggested.
Language eng
DOI 10.1097/MRM.0b013e32833a3dc9
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052215

Document type: Journal Article
Collection: School of Psychology
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