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Oral baclofen in children with cerebral palsy : a double-blind cross-over pilot study

Scheinberg, Adam, Hall, Kate, Lam, Lawrence T. and O'Flaherty, Stephen 2006, Oral baclofen in children with cerebral palsy : a double-blind cross-over pilot study, Journal of paediatrics and child health, vol. 42, no. 11, pp. 715-720, doi: 10.1111/j.1440-1754.2006.00957.x.

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Title Oral baclofen in children with cerebral palsy : a double-blind cross-over pilot study
Author(s) Scheinberg, Adam
Hall, Kate
Lam, Lawrence T.
O'Flaherty, Stephen
Journal name Journal of paediatrics and child health
Volume number 42
Issue number 11
Start page 715
End page 720
Total pages 6
Publisher Wiley-Blackwell Publishing
Place of publication Oxford, England
Publication date 2006
ISSN 1034-4810
Keyword(s) baclofen
cerebral palsy
clinical trial
oral administration
Summary Aim: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy. Methods: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire. Results: Fifteen children with mean age 7.4 years (SD = 2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13) = 4.5, P = 0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described. Conclusion: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.
Language eng
DOI 10.1111/j.1440-1754.2006.00957.x
Field of Research 179999 Psychology and Cognitive Sciences not elsewhere classified
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: School of Psychology
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