Does the longer application of anodal-transcranial direct current stimulaiton increase corticomotor excitability further? A pilot study

Jaberzadeh, Shapour, Bastani, Andisheh and Kidgell, Dawson 2012, Does the longer application of anodal-transcranial direct current stimulaiton increase corticomotor excitability further? A pilot study, Basic and clinical neuroscience, vol. 3, no. 4, pp. 28-35.

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Title Does the longer application of anodal-transcranial direct current stimulaiton increase corticomotor excitability further? A pilot study
Author(s) Jaberzadeh, Shapour
Bastani, Andisheh
Kidgell, Dawson
Journal name Basic and clinical neuroscience
Volume number 3
Issue number 4
Start page 28
End page 35
Total pages 8
Publisher Tehran University of Medical Sciences
Place of publication Tehran, Iran
Publication date 2012
ISSN 2228-7442
Keyword(s) transcranial direct current stimulation (tDCS)
transcranial magnetic stimulation (TMS)
corticomotor excitability
Summary Introduction: Anodal transcranial direct current stimulation (a-tDCS) of the primary motor cortex (M1) has been shown to be effective in increasing corticomotor excitability.
 
Methods: We investigated whether longer applications of a-tDCS coincide with greater increases in corticomotor excitability compared to shorter application of a-tDCS. Ten right-handed healthy participants received one session of a-tDCS (1mA current) with shorter (10 min) and longer (10+10 min) stimulation durations applied to the left M1 of extensor carpi radialis muscle (ECR). Corticomotor excitability following application of a-tDCS was assessed at rest with transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEP) and compared with baseline data for each participant.
 
Results: MEP amplitudes were increased following 10 min of a-tDCS by 67% (p = 0.001) with a further increase (32%) after the second 10 min of a-tDCS (p = 0.005). MEP amplitudes remained elevated at 15 min post stimulation compared to baseline values by 65% (p = 0.02).
 
Discussion: The results demonstrate that longer application of a-tDCS within the recommended safety limits, increases corticomotor excitability with after effects of up to 15 minutes post stimulation.
Language eng
Field of Research 110903 Central Nervous System
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052593

Document type: Journal Article
Collection: Centre for Physical Activity and Nutrition Research
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