In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS) and autoimmune responses directed against O&NS- damaged neoepitopes Maes, M., Kubera, M., Leunis, J. C., Berk, M., Geffard, M. and Bosmans, E. 2012, In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS) and autoimmune responses directed against O&NS- damaged neoepitopes, Acta psychiatrica scandinavica, vol. 127, no. 5, pp. 344-354, doi: 10.1111/j.1600-0447.2012.01908.x. Attached Files Name Description MIMEType Size Downloads Title In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS) and autoimmune responses directed against O&NS- damaged neoepitopes Author(s) Maes, M. Kubera, M. Leunis, J. C. Berk, M. orcid.org/0000-0002-5554-6946 Geffard, M. Bosmans, E. Journal name Acta psychiatrica scandinavica Volume number 127 Issue number 5 Start page 344 End page 354 Total pages 11 Publisher Wiley - Blackwell Publishing Place of publication Malden, Mass. Publication date 2012-05 ISSN 0001-690X 1600-0447 Keyword(s) depression inflammation leaky gut cytokines LPS oxidative stress chronic fatigue Summary Objective: Depression is accompanied by activation of immuno-inflammatory and oxidative and nitrosative stress (IO&NS) pathways, and increased IgM/IgA responses to lipopolysaccharide (LPS) of gram-negative commensal bacteria. The latter suggests that bacterial translocation has caused IgM/IgA responses directed against LPS. Bacterial translocation may drive IO&NS responses. Method: To examine the associations between IgM/IgA responses to LPS and IO&NS measurements, including plasma/serum interleukin-1 (IL-1), tumor necrosis factor (TNF)α, neopterin, lysozyme, oxidized LDL (oxLDL) antibodies, peroxides, and IgM (auto)immune responses against malondialdehyde (MDA), azelaic acid, phophatidyl inositol (Pi), NO-tryptophan and NO-tyrosine in depressed patients and controls. Results: We found significant positive associations between IgM/IgA responses to LPS and oxLDL antibodies, IgM responses against MDA, azelaic acid, Pi, NO-tryptophan, and NO-tyrosine. The IgA responses to LPS were correlated with lysozyme. There were no significant positive correlations between the IgM/IgA responses to LPS and IL-1 and neopterin. Conclusion: The findings show that in depression there is an association between increased bacterial translocation and lysozyme production, an antibacterial compound, O&NS processes, and autoimmune responses directed against O&NS generated neoantigenic determinants. It is suggested that bacterial translocation may drive IO&NS pathways in depression and thus play a role in its pathophysiology. Language eng DOI 10.1111/j.1600-0447.2012.01908.x Field of Research 119999 Medical and Health Sciences not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Grant ID NHMRC 1027315 NHMRC 1026265 Persistent URL http://hdl.handle.net/10536/DRO/DU:30052719 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 30 May 2013, 11:35:13 EST Thu, 30 May 2013, 15:42:54 EST Thu, 30 May 2013, 15:43:50 EST Thu, 30 May 2013, 15:46:10 EST Mon, 12 May 2014, 15:26:43 EST Tue, 10 Jun 2014, 07:24:12 EST Fri, 13 Jun 2014, 17:25:33 EST Filtered Full Citation counts:   Cited 101 times in TR Web of Science Cited 101 times in Scopus Search Google Scholar Access Statistics: 762 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 30 May 2013, 11:34:52 EST by Jane Moschetti

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