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Pathways to new drug discovery in neuropsychiatry

Berk, Michael 2012, Pathways to new drug discovery in neuropsychiatry, BMC medicine, vol. 10, no. 151, pp. 1-4.

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Title Pathways to new drug discovery in neuropsychiatry
Author(s) Berk, Michael
Journal name BMC medicine
Volume number 10
Issue number 151
Start page 1
End page 4
Publisher BioMed Central
Place of publication London, England
Publication date 2012
ISSN 1741-7015
Keyword(s) depression
bipolar disorder
diabetes
treatment
drug discovery
pathophysiology
Summary There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the mechanisms for identifying new drugs and new drug targets. Historically, the vast majority of agents have been discovered serendipitously or have been modifications of existing agents. Serendipitous discoveries, based on astute clinical observation or data mining, remain a valid option, as is illustrated by the suggestion in the paper by Wahlqvist and colleagues that treatment with sulfonylurea and metformin reduces the risk of affective disorder. However, the identification of agents targeting disorder-related biomarkers is currently proving particularly fruitful. There is considerable hope for genetics as a purist, pathophysiologically valid pathway to drug discovery; however, it is unclear whether the science is ready to meet this promise. Fruitful paradigms will require a break from the orthodoxy, and creativity and risk may well be the fingerprints of success.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052722

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.