Haase, Silvia, Bullen, Hayley E., Charnaud, Sarah C., Crabb, Brendan S., Gilson, Paul R. and de Koning Ward, Tania F. 2013, Host cell remodelling and protein trafficking. In Carlton, Jane M., Perkins, Susan L. and Deitsch, Kirk W. (ed), Malaria parasites : comparative genomics, evolution and molecular biology, Caister Academic Press, [Wymondham, England], pp.199-219.
Inside their respective vertebrate hosts, Plasmodium spp spend most of their life residing within hepatocytes and erythrocytes, with large-scale infection of the latter responsible for the clinical symptoms associated with malaria. These parasites extensively remodel these host cells for a variety of purposes relating to both pathogenesis and maintaining growth. Remodelling of the erythrocytic stage has been most intensively studied in P. falciparum and is the subject of this chapter. To help remodel their hosts these parasites export hundreds of proteins into the erythrocytic compartment. This principally alters the architecture of the erythrocyte, rendering the host membrane more permeable to solutes and nutrients, and also increasing the rigidity and adhesiveness of the infected erythrocyte. Moreover, because erythrocytes lack a secretory apparatus, the parasite must also export many additional proteins to help traffic other proteins to their correct destination within the host cell. The functions of some of these exported proteins will be discussed as will recent progress that has been made in unravelling how exported proteins gain access to the host compartment.
Field of Research
060599 Microbiology not elsewhere classified 060108 Protein Trafficking
Socio Economic Objective
970106 Expanding Knowledge in the Biological Sciences
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