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Host cell remodelling and protein trafficking Haase, Silvia, Bullen, Hayley E., Charnaud, Sarah C., Crabb, Brendan S., Gilson, Paul R. and de Koning Ward, Tania F. 2013, Host cell remodelling and protein trafficking, in Malaria parasites : comparative genomics, evolution and molecular biology, Caister Academic Press, [Wymondham, England], pp.199-219. Attached Files Name Description MIMEType Size Downloads Title Host cell remodelling and protein trafficking Author(s) Haase, Silvia Bullen, Hayley E. Charnaud, Sarah C. Crabb, Brendan S. Gilson, Paul R. de Koning Ward, Tania F. Title of book Malaria parasites : comparative genomics, evolution and molecular biology Editor(s) Carlton, Jane M. Perkins, Susan L. Deitsch, Kirk W. Publication date 2013 Chapter number 9 Total chapters 11 Start page 199 End page 219 Total pages 21 Publisher Caister Academic Press Place of Publication [Wymondham, England] Keyword(s) microbiology medical microbiology molecular microbiology genomics parasitology Summary Inside their respective vertebrate hosts, Plasmodium spp spend most of their life residing within hepatocytes and erythrocytes, with large-scale infection of the latter responsible for the clinical symptoms associated with malaria. These parasites extensively remodel these host cells for a variety of purposes relating to both pathogenesis and maintaining growth. Remodelling of the erythrocytic stage has been most intensively studied in P. falciparum and is the subject of this chapter. To help remodel their hosts these parasites export hundreds of proteins into the erythrocytic compartment. This principally alters the architecture of the erythrocyte, rendering the host membrane more permeable to solutes and nutrients, and also increasing the rigidity and adhesiveness of the infected erythrocyte. Moreover, because erythrocytes lack a secretory apparatus, the parasite must also export many additional proteins to help traffic other proteins to their correct destination within the host cell. The functions of some of these exported proteins will be discussed as will recent progress that has been made in unravelling how exported proteins gain access to the host compartment. ISBN 9781908230072 190823007X Language eng Field of Research 060599 Microbiology not elsewhere classified 060108 Protein Trafficking Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category B1 Book chapter Copyright notice ©2013, Caister Academic Press Persistent URL http://hdl.handle.net/10536/DRO/DU:30052774 Document type: Book Chapter Collection: School of Medicine   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 03 Jun 2013, 11:31:34 EST Tue, 04 Jun 2013, 08:49:01 EST Wed, 05 Jun 2013, 09:29:43 EST Wed, 05 Jun 2013, 09:43:07 EST Tue, 10 Sep 2013, 15:23:36 EST Thu, 19 Dec 2013, 14:29:26 EST Mon, 12 May 2014, 15:27:10 EST Filtered Full Access Statistics: 74 Abstract Views, 4 File Downloads  -  Detailed Statistics Created: Mon, 03 Jun 2013, 11:31:19 EST by Jane Moschetti

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