Neuroendocrine neoplasms of the GI tract : the role of cytotoxic chemotherapy

Khasraw, Mustafa, Yap, Saw Yee and Ananda, Sumitra 2013, Neuroendocrine neoplasms of the GI tract : the role of cytotoxic chemotherapy, Expert review of anticancer therapy, vol. 13, no. 4, pp. 451-459.

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Title Neuroendocrine neoplasms of the GI tract : the role of cytotoxic chemotherapy
Author(s) Khasraw, MustafaORCID iD for Khasraw, Mustafa
Yap, Saw Yee
Ananda, Sumitra
Journal name Expert review of anticancer therapy
Volume number 13
Issue number 4
Start page 451
End page 459
Total pages 9
Publisher Expert Reviews
Place of publication London, England
Publication date 2013
ISSN 1473-7140
Summary Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of neoplasms derived from peptide- and amine-secreting cells of the neuroendocrine system. NENs commonly arise in the GI tract but can arise in most organs of the body. NENs in different organs share many common pathologic features. Although the incidence of NENs is not high, the prevalence is not low because many patients may live relatively long periods without major symptoms from the disease. While many of these tumors lead an indolent clinical course, they constitute a therapeutic challenge when they progress, metastasize and become symptomatic. Treatment requires a multidisciplinary approach including cytotoxic chemotherapy. Almost all clinical trials investigating cytotoxic chemotherapy in NENs are small single-arm studies and guidelines are derived from expert opinion and from extrapolating results from small cell lung cancer studies. This article briefly reviews NENs before focusing on reviewing data on the role of cytotoxic chemotherapy studies in NENs.
Language eng
Field of Research 111203 Cancer Genetics
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: School of Medicine
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