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Gender differences in first episode psychotic mania

Cotton, Sue M., Lambert, Martin, Berk, Michael, Schimmelmann, Benno G., Butselaar, Felicity J., McGorry, Patrick D. and Conus, Philippe 2013, Gender differences in first episode psychotic mania, BMC psychiatry, vol. 13, Article 82, pp. 1-8.

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Title Gender differences in first episode psychotic mania
Author(s) Cotton, Sue M.
Lambert, Martin
Berk, Michael
Schimmelmann, Benno G.
Butselaar, Felicity J.
McGorry, Patrick D.
Conus, Philippe
Journal name BMC psychiatry
Volume number 13
Season Article 82
Start page 1
End page 8
Total pages 8
Publisher BioMed Central
Place of publication London, England
Publication date 2013
ISSN 1471-244X
Keyword(s) gender
mania
psychosis
bipolar disorder
Summary Background : The aim of this paper was to delineate the impact of gender on premorbid history, onset, and 18 month outcomes of first episode psychotic mania (FEPM) patients.
Methods : Medical file audit assessment of 118 (male = 71; female = 47) patients with FEPM aged 15 to 29 years was undertaken on clinical and functional measures.
Results : Males with FEPM had increased likelihood of substance use (OR = 13.41, p < .001) and forensic issues (OR = 4.71, p = .008), whereas females were more likely to have history of sexual abuse trauma (OR = 7.12, p = .001). At service entry, males were more likely to be using substances, especially cannabis (OR = 2.15, p = .047), had more severe illness (OR = 1.72, p = .037), and poorer functioning (OR = 0.96, p = .045). During treatment males were more likely to decrease substance use (OR = 5.34, p = .008) and were more likely to be living with family (OR = 4.30, p = .009). There were no gender differences in age of onset, psychopathology or functioning at discharge.
Conclusions : Clinically meaningful gender differences in FEPM were driven by risk factors possibly associated with poor outcome. For males, substance use might be associated with poorer clinical presentation and functioning. In females with FEPM, the impact of sexual trauma on illness course warrants further consideration.
Language eng
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052825

Document type: Journal Article
Collections: School of Medicine
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