Marine polyunsaturated fatty acids and cancer therapy

Vaughan, V. C., Hassing, M. R. and Lewandowski, P. A. 2013, Marine polyunsaturated fatty acids and cancer therapy, British journal of cancer, vol. 108, no. 3, pp. 486-492.

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Title Marine polyunsaturated fatty acids and cancer therapy
Author(s) Vaughan, V. C.
Hassing, M. R.
Lewandowski, P. A.
Journal name British journal of cancer
Volume number 108
Issue number 3
Start page 486
End page 492
Total pages 7
Publisher Nature Publishing
Place of publication London, England
Publication date 2013
ISSN 0007-0920
1532-1827
0306-9443
Keyword(s) polyunsaturated fatty acids
eicosapentaenoic acid
docosahexaenoic acid
chemotherapy
cachexia
Summary Polyunsaturated fatty acids (PUFAs) derived from marine sources, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are widely consumed as supplements within the community. However, the use of marine PUFAs in a therapeutic context is also increasing in patients receiving treatment for a range of cancer types. On balance, the literature suggests that marine PUFAs have potential as an effective adjuvant to chemotherapy treatment, may have direct anticancer effects, and may help ameliorate some of the secondary complications associated with cancer. Although a range of doses have been trialled, it would appear that supplementation of fish oil (>3 g per day) or EPA/DHA (>1 g EPA and >0.8 g DHA per day) is associated with positive clinical outcomes. However, further research is still required to determine the mechanisms via which marine PUFAs are mediating their effects. This review summarises our current understanding of marine PUFAs and cancer therapy.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30052874

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 06 Jun 2013, 12:53:38 EST by Paul Lewandowski

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