Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus

Sanigorski, A., Cameron-Smith, D., Lewandowski, P., Walder, K., de Silva, A., Morton, G. and Collier, G. R. 2000, Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus, Journal of endocrinology, vol. 164, no. 1, pp. 45-50, doi: 10.1677/joe.0.1640045.

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Title Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus
Author(s) Sanigorski, A.ORCID iD for Sanigorski, A.
Cameron-Smith, D.
Lewandowski, P.
Walder, K.ORCID iD for Walder, K.
de Silva, A.
Morton, G.
Collier, G. R.
Journal name Journal of endocrinology
Volume number 164
Issue number 1
Start page 45
End page 50
Total pages 6
Publisher BioScientifica
Place of publication Bristol, England
Publication date 2000-01
ISSN 0022-0795
Keyword(s) adipocytes
body composition
body weight
gene expression
lipoprotein lipase
cytoplasmic and nuclear receptors
transcription factors
Summary We examined the effects of leptin treatment on the expression of key genes in adipocyte metabolism in Psammomys obesus (P. obesus), a polygenic rodent model of obesity. Lean and obese P. obesus were given three daily intraperitoneal injections of either saline or leptin (total of 45 mg/kg per day) for 7 days. In lean animals, leptin treatment led to reductions in food intake, body weight and fat mass. Pair-fed animals matched for the reduction in food intake of the lean leptin-treated animals demonstrated similar reductions in body weight and fat mass. In obese P. obesus, leptin treatment failed to have any effect on body weight or body fat mass, indicating leptin resistance. Lipoprotein lipase, hormone-sensitive lipase and peroxisome proliferator activated receptor gamma 2 mRNA levels were significantly reduced in lean leptin-treated animals, whereas pair-fed animals were similar to lean controls. Uncoupling protein 2 and glycerol phosphate acyltransferase were also reduced in the lean leptin-treated animals, but not significantly so. Obese animals did not show any gene expression changes after leptin treatment. In conclusion, high circulating concentrations of leptin in lean P. obesus resulted in decreased gene expression of a number of key lipid enzymes, independent of changes in food intake, body weight and fat mass. These effects of leptin were not found in obese P. obesus.
Language eng
DOI 10.1677/joe.0.1640045
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: School of Health Sciences
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Created: Wed, 19 Jun 2013, 10:07:52 EST by Paul Lewandowski

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