Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus

Walder, K., Lewandowski, P., Morton, G., Sanigorski, A., de Silva, A., Zimmet, P. and Collier, G. R. 1999, Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus, International journal of obesity, vol. 23, no. 1, pp. 83-89.

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Title Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM : Psammomys obesus
Author(s) Walder, K.
Lewandowski, P.
Morton, G.
Sanigorski, A.
de Silva, A.
Zimmet, P.
Collier, G. R.
Journal name International journal of obesity
Volume number 23
Issue number 1
Start page 83
End page 89
Total pages 7
Publisher Nature Publishing Group
Place of publication London, England
Publication date 1999-01
ISSN 0307-0565
1476-5497
Keyword(s) Psammomys obesus
obesity treatment
leptin resistance
Summary OBJECTIVE: To investigate the effects of leptin administration to Psammomys obesus, a polygenic animal model of obesity and type 2 diabetes mellitus.

DESIGN: Longitudinal intervention study utilising three separate leptin treatment protocols lasting 7-14 d.

MEASUREMENTS: Body weight and food intake were measured daily, body fat and muscle content were estimated by carcass analysis on completion of the study. Blood glucose, plasma insulin, leptin, triglycerides and cholesterol were measured at baseline and twice each week during the study.

RESULTS: Relatively high doses of leptin were required to significantly reduce food intake and body fat content in lean Psammomys obesus, but had no discernible effect on their obese littermates.

CONCLUSION: As a species, Psammomys obesus appear to be relatively insensitive to the effects of leptin administration, compared with other rodents. Obese Psammomys obesus are leptin resistant relative to their lean littermates.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30053021

Document type: Journal Article
Collection: School of Nutrition and Public Health
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