The role of lipogenesis in the development of obesity and diabetes in Israeli sand rats (Psammomys obesus)

Lewandowski, Paul A., Cameron-Smith, David, Jackson, Colleen J., Kultys, Eva R. and Collier, Greg R. 1998, The role of lipogenesis in the development of obesity and diabetes in Israeli sand rats (Psammomys obesus), Journal of Nutrition, vol. 128, no. 11, pp. 1984-1988.

Attached Files
Name Description MIMEType Size Downloads

Title The role of lipogenesis in the development of obesity and diabetes in Israeli sand rats (Psammomys obesus)
Author(s) Lewandowski, Paul A.
Cameron-Smith, David
Jackson, Colleen J.
Kultys, Eva R.
Collier, Greg R.
Journal name Journal of Nutrition
Volume number 128
Issue number 11
Start page 1984
End page 1988
Total pages 5
Publisher American Society for Nutrition
Place of publication Bethesda, Md.
Publication date 1998-11
ISSN 0022-3166
1541-6100
Keyword(s) hyperglycemia
hyperinsulinemia
lipogenesis
Psammomys obesus
Summary Obesity and diabetes in Israeli sand rats, Psammomys obesus, occur with the sequential transition of animals from normal insulin sensitivity to impaired insulin sensitivity, accompanied by increased adiposity, prior to insulin resistance and obesity, in a manner similar to susceptible human populations. The current study was designed to examine the role of de novo lipid synthesis in the development of excessive weight gain in P. obesus. Sand rats were classified at 12 wk of age into three groups: A, normoglycemic normoinsulinemic; B, normoglycemic hyperinsulinemic; C, hyperglycemic hyperinsulinemic, based on glucose and insulin responses in fed sand rats. Body weight, liver weight, white adipose tissue (WAT) mass and food intake were significantly elevated in Group C compared to Group A (P < 0.05). Lipogenic rate was measured by the amount of 3H incorporated into subscapular brown adipose tissue (BAT), epidiymal WAT and liver per hour, from sand rats with and without access to food. No difference in lipogenic rate was found between the groups in BAT, indicating that this tissue is of minor importance in whole body lipogenesis in P. obesus. In the WAT there was a greater lipogenic rate with the development of obesity and hyperinsulinemia (Group B vs. Group A) but no difference in the liver. However, the onset of hyperglycemia (Group C) further stimulated WAT lipogenesis and initiated increased hepatic lipogenesis, both of which contributed to the pre-existing obesity. This study suggests that elevated lipogenesis is not the primary cause of obesity in P. obesus, as lipogenic rate only markedly increases after obesity is already present in hyperglycemic animals.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30053022

Document type: Journal Article
Collection: School of Nutrition and Public Health
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in TR Web of Science
Scopus Citation Count Cited 8 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 10 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Wed, 19 Jun 2013, 10:21:27 EST by Paul Lewandowski

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.